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. 1987 Nov 1;7(11):3793–3802. doi: 10.1523/JNEUROSCI.07-11-03793.1987

Quantitative distribution of the glycine receptor in the auditory brain stem of the gerbil

DH Sanes 1, WA Geary 1, GF Wooten 1, EW Rubel 1
PMCID: PMC6569021  PMID: 2890726

Abstract

The concentration and relative distribution of glycine receptors were determined for gerbil brain stem auditory nuclei using 3H-strychnine and quantitative autoradiographic techniques. Significant binding was observed in the anteroventral cochlear nucleus, the dorsal cochlear nucleus, the lateral superior olivary nucleus, and the inferior colliculus. A non-uniform distribution of binding was seen in 3 of these nuclei, such that the greatest concentration of glycine receptors was located in the high-frequency regions. An analysis of neuron soma density suggested that the amount of post-synaptic membrane could partially explain the distribution of receptor.


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