Abstract
Research is needed to determine targets for interventions to increase pre-exposure prophylaxis (PrEP) uptake. The Information-Motivation-Behavioral Skills (IMB) model has not been tested for PrEP use among men who have sex with men (MSM). Men and transgender women and men were surveyed at a community event in the Midwest in 2016 (N=476, 60% White, Mage=35). New measures assessed PrEP knowledge, attitudes, stigma, descriptive and subjective norms, and intentions, and participants reported on PrEP use. We tested the IMB model for a subsample of HIV-negative MSM and transgender individuals (N=357) using structural equation modeling. Only 12% of participants used PrEP. New measures performed well and were reliable (αs=.83-.94). Structural models generally supported the IMB model: knowledge, stigma, and self-efficacy were directly associated with use, and attitudes, stigma, and descriptive norms had indirect effects on use via self-efficacy. The IMB model may be useful when developing PrEP interventions for MSM.
Keywords: pre-exposure prophylaxis, information-motivation-behavioral skills model, men who have sex with men, HIV prevention
INTRODUCTION
HIV continues to present a critical health challenge, with nearly 50,000 new HIV infections each year in the U.S. (1). Men who have sex with men (MSM) carry the highest risk for acquiring HIV infection, accounting for two-thirds of new infections (2). However, new biomedical approaches to prevention show potential to reduce HIV incidence in MSM. Pre-exposure prophylaxis (PrEP), a daily medication similar to antiretroviral therapy, reduces the risk of HIV infection by 44–88% (3–7) in at-risk populations, with even greater reductions among those who are most adherent (8–10). Thus, PrEP could make a significant impact on the HIV epidemic. Uptake has been growing consistently (11–15), but use of PrEP has not become widespread enough to impact HIV incidence (16). It is estimated that 1.2 million adults in the U.S. would benefit from being on PrEP (17), but only an estimated 77,120 used PrEP in 2016 (18).
Research is needed to determine appropriate targets for interventions to increase PrEP uptake. One basis for HIV prevention interventions is the Information-Motivation-Behavioral Skills (IMB) model (19, 20). The IMB model theorizes that that information about a target behavior (i.e., knowledge) and motivation to perform the behavior (based on factors such as attitudes, stigma, and social norms) lead to the development of relevant behavioral skills (i.e., individuals’ objective and perceived abilities to perform the target behavior). These behavioral skills then contribute directly to behavior and also partially mediate associations between information and motivation and behavior itself. Although there are some critiques that health behavior theories such as the IMB model do not sufficiently address socioeconomic or social network factors (21), this model is generally well-supported by research (22, 23), typically explaining 35–51% of the variance in HIV-related behaviors such as condom use and medication adherence (24).
The IMB model has served as a guide for prevention interventions focused on condom use, and it has recently been proposed to be a useful model for explaining PrEP use (25). Prior research provides some evidence that information, motivation, and behavioral skills may be influences on PrEP uptake, as reviewed by Dubov et al. (25). In terms of information, studies tend to show relatively low PrEP awareness among MSM (26–31). Surveys over time suggest that PrEP awareness and use are both increasing (14, 32–35), although awareness may not be growing in all populations (31), and some studies suggest that increases in awareness are not accompanied by increases in willingness to use PrEP or actual use (32, 33). One study with people who use drugs (PWUD) at higher risk showed that those with greater PrEP knowledge had greater confidence they could use PrEP, although knowledge was not directly associated with willingness to use PrEP (36). Very few studies have included assessments of PrEP knowledge, and thus there is little evidence about associations between knowledge and PrEP intentions or use.
Motivational factors such as attitudes, stigma, and social norms have also been suggested as potential influences on PrEP uptake. Negative PrEP attitudes have been reported as reasons for declining PrEP in studies of MSM (28, 37). Additionally, demonstration projects and qualitative studies have reported PrEP stigma as a barrier to uptake (38–45). Studies have suggested that peer norms may influence PrEP perceptions and intentions, with MSM indicating that few members of their social networks take PrEP (46) and being more interested in PrEP when they believe their friends would use it (47). Research has also suggested that negative partner subjective norms may be perceived as barriers to PrEP use (39). In a study of PWUD at higher risk, motivation to use PrEP (conceptualized as concerns about HIV, concerns about PrEP side effects, and feelings of responsibility to contribute to HIV prevention efforts) was associated with PrEP behavioral skills, but not directly associated with willingness to use PrEP (36). Notably, few studies have directly investigated associations between attitudes, stigma, or social norms and PrEP intentions or use.
Finally, lack of behavioral skills and low self-efficacy have been described as barriers to PrEP uptake. For example, in qualitative studies, men have discussed inability to negotiate PrEP with sexual partners and concerns about their capacity to adhere to a daily medication as barriers to PrEP initiation (48–50). Among Black MSM in LA, self-efficacy for obtaining and filling a PrEP prescription and managing PrEP side effects correlated with adoption intentions (51). Additionally, one study found that self-perceived ability to discuss PrEP with a provider was correlated with PrEP intentions (52).
Thus, preliminary evidence suggests that the IMB model could be applied to explain PrEP use. Additionally, one recent study has specifically tested the IMB model for PrEP willingness in a sample of PWUD at higher risk, finding support, with PrEP information and motivation associated with PrEP-related behavioral skills and behavioral skills associated with willingness to use PrEP (36). However, the IMB model has not yet been tested for PrEP intentions or use among MSM, and, in fact, no quality measures of PrEP information, motivation, or behavioral skills exist for the general population. Testing and refining measures of these constructs, as well as exploring associations between these constructs and PrEP intentions and behaviors will provide a foundation for future PrEP-related intervention trials.
Therefore, to explore factors associated with MSM’s PrEP intentions and use, we developed new measures using the framework of the IMB model, including measures of PrEP knowledge, PrEP attitudes, PrEP stigma, PrEP descriptive and subjective norms, PrEP self-efficacy, and PrEP intentions. We then evaluated the psychometric characteristics of these measures by assessing individual items and inter-item correlations, performing confirmatory factor analysis (CFA), calculating reliability, and testing for differential item functioning (DIF). Finally, we explored whether the IMB model explained MSM’s PrEP intentions and use in a community sample.
METHODS
Participants and Procedure
Participants completed an anonymous survey on paper at a community event in a mid-sized city in the Midwestern U.S. in June 2016. Participants were recruited by research staff at a table in a heavily trafficked Health and Wellness area at the event. To be eligible for participation, individuals had to be 18 years of age or older; identify as male, a man, or transgender; and not be visibly intoxicated or impaired. Demographic characteristics of the participants are included in Table 1. For measurement evaluation, the sample included 476 participants who identified as male or transgender. We tested the IMB model with a subsample of participants who were HIV-negative men and transgender women and men who engaged in sex with men. Participants were offered a small cash incentive or gift ($5 in value) in return for their time. Participation took approximately 10–20 minutes. The Medical College of Wisconsin Institutional Review Board approved all procedures.
Table 1.
Measurement Evaluation (N = 476) % / M (SD) |
IMB Model (N = 357) % / M (SD) |
|
---|---|---|
Gender identity | ||
Male | 91% | 93% |
Transgender woman | 3% | 3% |
Transgender man | 4% | 3% |
Other gender | 2% | 2% |
Age | 35.14 (14.30) | 35.39 (13.98) |
Race | ||
White | 60% | 61% |
Black | 22% | 21% |
Multiracial | 7% | 7% |
Other race | 11% | 9% |
Unreported | 2% | 2% |
Latino ethnicity | 15% | 14% |
Unemployed | 11% | 10% |
Current student | 23% | 24% |
Sexual partners | ||
Men only | 66% | 81% |
Women only | 15% | -- |
Men and women | 13% | 17% |
Does not have sex | 4% | -- |
Partner gender(s) not reported | 2% | 3% |
HIV status | ||
HIV positive | 7% | -- |
HIV negative | 71% | 81% |
Unknown HIV status | 17% | 13% |
Unreported HIV status | 6% | 6% |
Measures
Measurement development process.
New measure items were developed and reviewed by experts in HIV prevention and HIV providers. True-false knowledge items were developed by consulting PrEP informational materials from governmental and public health organizations, including AIDS.gov, SFHIV.org, CDC.gov, ProjectInform.org, and ACToronto.org. Items assessing knowledge, attitudes, stigma, norms, self-efficacy, and intentions were modeled after those from scales in other areas of HIV prevention and sexual health (53–62). The initial survey included 18 items assessing knowledge, 18 assessing attitudes, 6 assessing stigma, 6 assessing descriptive norms, 11 assessing subjective norms, 11 assessing self-efficacy, and 4 assessing intentions. The number of items in scales was reduced based on assessment of item distributions, inter-item correlations, CFA models, and DIF, as described below. The final scales are described here, and full measures are available in the Appendix.
Demographics assessed included age, gender identity, race and ethnicity, relationship status, employment status, income, student status, and place of residence. We coded whether participants identified as transgender (0 = no, 1 = yes). For relationship status, a dummy variable indicated whether or not participants considered themselves to be currently involved in a monogamous sexual relationship (“a committed relationship where you both have agreed to only have sex with each other,” 0 = no, 1 = yes). For employment status, participants indicated whether they were currently unemployed and looking for work (0 = no, 1 = yes). Participants indicated their monthly income on a 6-point scale (1 = $0-$1,000, 6 = $5,001+). Participants reported whether they were currently enrolled in school full-or part-time (0 = no, 1 = yes). Finally, we coded whether participants currently lived in a city as opposed to a suburban area, a small town, or a rural area (0 = no, 1 = yes).
Information: PrEP knowledge.
Knowledge was assessed with 13 items (e.g., “You should not use PrEP if you don’t know your HIV status”; see the Appendix for all items). Participants had three response options: True, False, or Don’t Know. Items were scored as correct (1) or incorrect/don’t know (0); higher scores indicated more knowledge of PrEP.
Motivation: PrEP attitudes.
Attitudes were assessed with 5 items (e.g., “PrEP is effective at preventing HIV”; see the Appendix for all items). Responses were on a 5-point scale from strongly disagree (1) to strongly agree (5), with higher scores indicating more positive attitudes toward PrEP.
Motivation: PrEP stigma.
Stigma was assessed with 5 items (e.g., “People who take PrEP are promiscuous”; see the Appendix for all items). Responses were on a 5-point scale from strongly disagree (1) to strongly agree (5), with higher scores indicating more PrEP stigma.
Motivation: PrEP descriptive norms.
Descriptive norms were assessed with 6 items focusing on how people in the participants’ communities and the participants’ friends would feel about (1) learning more about PrEP, (2) talking with their doctors about PrEP, and (3) taking PrEP (e.g., “People in my community would consider taking PrEP”; see the Appendix for all items). Responses were on a 5-point scale from strongly disagree (1) to strongly agree (5), with higher scores indicating more positive norms. Two subscales assessed community and friend norms; these subscales were highly correlated (r = .75) and combined for structural analyses.
Motivation: PrEP subjective norms.
Subjective norms were assessed with 6 items assessing how participants’ friends and sexual partner(s) would respond were the participant to take PrEP (e.g., “My friends would be supportive of me using PrEP”; see the Appendix for all items). Responses were on a 5-point scale from strongly disagree (1) to strongly agree (5), with higher scores indicating more positive norms. Two subscales assessed friend and sexual partner norms; these subscales were highly correlated (r = .83) and combined for structural analyses.
Behavioral skills: PrEP self-efficacy.
Participants reported how difficult it would be for them to engage in 8 behaviors related to PrEP use (e.g., “How difficult would it be for you to visit a doctor who can provide PrEP?”; see the Appendix for all items). Responses were on a scale from very hard to do (1) to very easy to do (4), with higher scores indicating greater self-efficacy.
PrEP intentions.
Intentions were assessed with 3 items asking about PrEP behaviors in the next three months (e.g., “During the next three months, I will talk to a health care provider about PrEP”; see the Appendix for all items). Responses were on a scale from definitely will not do (1) to definitely will do (4), with higher scores indicating greater intentions to use PrEP.
PrEP use.
Participants reported whether they were currently taking PrEP.
Data Analysis
Missing data.
To reduce participant demand, a well-established planned missingness approach (63) was used such that each individual participant completed only a subset of the new PrEP items assessing knowledge, attitudes, stigma, descriptive and subjective norms, and self-efficacy. Specifically, all participants completed 74–77% of these items, including 2–4 anchor items perceived as central to each scale along with approximately two-thirds of remaining items; the form which each participant completed was randomly determined. Aside from planned missing data, missing data was relatively rare. To address missing data, we used a full-information maximum likelihood (FIML) estimator (for assessment of the new PrEP measures) and multiple imputation (MI, for the structural models), both modern methods for dealing with missing data which allowed us to maintain the maximum sample size and avoid biases associated with complete case analysis or single imputations (64).
Assessment of new PrEP measures.
To test the functioning of the various PrEP measures, we followed strategies described in the literature (65). We first examined descriptive statistics and item correlations to check for highly skewed or unbalanced distributions and excessively low or high inter-item correlations. We then used CFA to assure the unidimensionality of scales, strong factor loadings, and good model fit. Model fit was assessed using traditional fit indices (66), including the comparative fit index (CFI); the Tucker-Lewis index (TLI); and the root-mean-square error of approximation (RMSEA). Good fit is indicated by CFI and TLI values greater than .95 and RMSEA values less than .05, and acceptable fit by CFI and TLI values over .90 and RMSEA values less than .06 (66, 67). Cronbach’s alpha was used as an additional assessment of the degree of internal consistency. Because we desired measures that functioned well for individuals of different ages, races and ethnicities, and socioeconomic statuses, we also analyzed scale items for and attempted to minimize DIF, which occurs when two individuals with similar levels of an underlying construct (e.g., knowledge) have different probabilities of answering a particular item in a specific way (e.g., of correctly identifying a specific knowledge item as true or false) (68, p. 93). To do this, we used moderated nonlinear factor analysis (MNLFA) in Mplus 7.4 as described by Bauer (69), testing for DIF based on age, race (non-Latino Whites vs. those of all other races/ethnicities), and income. These analyses were performed separately for each PrEP construct. Additionally, they were first performed on one randomly-selected exploratory half of the sample, with the second half of the sample serving as a confirmatory sample. Finally, when we proceeded to structural modeling, we tested the discriminant validity of our various PrEP constructs as well as their associations with PrEP intentions and use.
Testing the IMB for PrEP.
Structural equation modeling (SEM) in Mplus was used to test the IMB model. The IMB constructs as well as intentions were modeled as latent variables, which were identified by fixing variances at 1. Individual items for each construct were grouped into three parcels of items per construct representing average scores on sets of items; these parcels served as the indicators for the latent constructs. Parcels were formed based on the balancing of factor loadings (70).
We first fit a measurement model including all latent constructs to assure latent constructs were adequate representations. We then constructed separate structural models for use (including all HIV-negative men and transgender women and men who have sex with men) and intentions (including only those not taking PrEP). In these models, directional paths led from knowledge, attitudes, stigma, descriptive norms, and subjective norms to self-efficacy and use/intentions, and from self-efficacy to use/intentions, in line with the IMB model. Additionally, paths led from demographic covariates to all constructs; covariate paths were maintained in the model if they were significant at the p < .10 level. Knowledge, attitudes, stigma, descriptive norms, and subjective norms were all allowed to correlate.
The PrEP use model was fit using a robust weighted least squares (WLSMV) estimator appropriate for categorical outcomes, while the PrEP intentions model was fit using a full information maximum likelihood estimator robust to non-normality (the MLR estimator; 71). Model fit was again assessed using traditional fit indices (66). We report standardized factor loadings, correlations, and unstandardized linear and probit regression coefficients (for continuous and categorical outcomes, respectively). When testing mediation, 95% CIs were calculated using the distribution-of-the-product method in RMediation (72). This is recommended given the non-normal distribution of indirect effects. For indirect effects, unstandardized coefficients and 95% CIs are reported.
RESULTS
Assessment of New PrEP Measures
For all items, we evaluated item distributions and inter-item correlations, fit a CFA model, evaluated reliability, and tested for DIF. Refined versions of all scales had good CFA model fits, were reliable (αs = .83-.94), and demonstrated minimal evidence of DIF based on age, race/ethnicity, and income. Key information from these evaluations is presented in Table 2; further information is available from the author.
Table 2.
PrEP Scale | Items |
α | CFA Fit, Exploratory Sample (n = 236) |
CFA Fit, Confirmatory Sample (n = 240) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Initial | Final | Χ2 (df) | RMSEA | CFI | TLI | Factor Loadings | Χ2 (df) | RMSEA | CFI | TLI | Factor Loadings | ||
Knowledge | 18 | 13 | .90 | 97.00 (65)** | .05 | .99 | .99 | ≥.65, ps < .001 | 87.46 (65)* | .04 | .99 | .99 | ≥.63, ps < .001 |
Attitudes | 18 | 5 | .79 | 2.12 (5) | .000 | 1.00 | 1.05 | ≥.58, ps < .001 | 3.93 (5) | .000 | 1.00 | 1.01 | ≥.63, ps < .001 |
Stigma | 6 | 5 | .83 | 8.03 (5) | .05 | .99 | .97 | ≥.44, ps < .001 | 7.04 (5) | .04 | .99 | .98 | ≥.36, ps < .001 |
Descriptive Norms | 6 | 6 | .93 | 5.16 (5) | .01 | 1.00 | .999 | ≥.81, ps < .001 | 2.53 (5) | .000 | 1.00 | 1.02 | ≥.83, ps < .001 |
Subjective Norms | 11 | 6 | .94 | 7.72 (8) | .000 | 1.00 | 1.00 | ≥.86, ps < .001 | 4.74 (8) | .000 | 1.00 | 1.04 | ≥.83, ps < .001 |
Self-Efficacy | 11 | 8 | .87 | 65.99 (20)*** | .10 | .97 | .96 | ≥.69, ps < .001 | 59.45 (20)*** | .09 | .98 | .97 | ≥.59, ps < .001 |
Intentions | 4 | 3 | .90 | -- | -- | -- | -- | ≥.91, ps < .001 | -- | -- | -- | -- | ≥.90, ps < .001 |
* p < .05
** p < .01
*** p < .001
Notes. PrEP = Pre-Exposure Prophylaxis; CFA = confirmatory factor analysis; RMSEA = root-mean-square error of approximation; CFI = comparative fit index; TLI = Tucker-Lewis index.
Descriptive Information
Focusing on the subsample of participants who were HIV-negative men and transgender women and men who engaged in sex with men, only 12% of participants were taking PrEP, but 69% had heard of PrEP and 37% said they would probably or definitely start taking PrEP in the next 3 months (for intentions scale, M = 2.63 on a 1-to-4 scale, SD = 0.88). Participants answered less than half (M = 45%) of the PrEP knowledge items correctly on average (M = 5.83 items out of 13, SD = 4.08). Attitudes toward PrEP were generally positive (M = 3.75 on a 1-to-5 scale, SD = 0.75), while PrEP stigma was low to moderate (M = 2.50 on a 1-to-5 scale, SD =0.94). Both descriptive and subjective norms were relatively positive (Ms = 3.76 and 4.10 on 1-to-5 scales, respectively, SDs = 0.88 and 0.87). In terms of self-efficacy, participants viewed starting and taking PrEP as “somewhat easy to do” on average (M = 3.14 on a 1-to-4 scale, SD = 0.63). Further descriptive information related to individual scale items is available from the author.
Measurement Model
A measurement model including latent constructs representing knowledge, attitudes, stigma, descriptive norms, subjective norms, and intentions fit the data well, Χ2(131, N = 357) = 257.77, RMSEA = .05, CFI = .96, TLI = .95. All factor loadings were positive and highly significant, ps < .0001. As expected, all IMB constructs were correlated with one another and with intentions. Knowledge was positively correlated with attitudes, r = 0.53, p < .001, descriptive norms, r = 0.24, p < .001, subjective norms, r = 0.30, p < .001, self-efficacy, r = 0.27, p < .001, and intentions, r = 0.20, p = .001. Attitudes were positively correlated with descriptive norms, r = 0.52, p < .001, subjective norms, r = 0.67, p < .001, self-efficacy, r = 0.43, p < .001, and intentions, r = 0.40, p < .001. Descriptive norms were positively correlated with subjective norms, r = 0.65, p < .001, self-efficacy, r = 0.42, p < .001, and intentions, r = 0.39, p < .001. Subjective norms were positively correlated with self-efficacy, r = 0.38, p < .001, and intentions, r = 0.34, p < .001. Self-efficacy was positively correlated with intentions, r = 0.39, p < .001. Stigma was negatively correlated with knowledge, r = −0.37, p < .001, attitudes, r = −0.28, p <.001, descriptive norms, r = −0.31, p < .001, subjective norms, r = −0.26, p < .001, self-efficacy, r = −0.32, p < .001, and intentions, r = −0.14, p < .05.
Structural Models
Looking at all HIV-negative men and transgender women and men who have sex with men, the model for PrEP use (Figure 1) fit the data well, Χ2(249, N = 357) = 308.57, RMSEA =.03, CFI = .96, TLI = .96. Attitudes, stigma, and descriptive norms predicted self-efficacy, B = 0.28 (0.12), p < .05, B = −0.20 (0.06), p = .001, and B = 0.22 (0.09), p < .01, respectively. Those with more PrEP stigma reported lower self-efficacy for PrEP use, while those who felt more positively toward PrEP and those with more positive descriptive norms reported higher self-efficacy for PrEP use. Knowledge, stigma, and self-efficacy predicted use, B = 0.28 (0.09), p < .01, B = −0.18 (0.08), p < .05, and B = 0.29 (0.10), p = .001, respectively. Thus, those who knew more about PrEP and those with more self-efficacy for use were more likely to be current PrEP users, while those holding more PrEP stigma were less likely to be users. However, subjective norms were not associated with either self-efficacy or use. In line with the IMB model, attitudes, stigma, and descriptive norms had indirect effects on use via self-efficacy (attitudes: B = 0.08 [0.04], 95% CI = 0.01, 0.18, p < .05; stigma: B = −0.06 [0.03], 95% CI = −0.12, −0.01, p < .01; descriptive norms: B = 0.06 [0.03], 95% CI = 0.01, 0.14, p < .01). IMB constructs and demographics explained 57% of the variance in use.
Looking only at those participants not yet using PrEP, the model for PrEP use intentions (Figure 2) had acceptable fit, Χ2(267, N = 310) = 417.37, RMSEA = .04, CFI = .95, TLI = .94. Stigma and descriptive norms predicted self-efficacy, B = −0.18 (0.09), p < .05, and B = 0.26 (0.12), p < .05, respectively; those with more PrEP stigma reported lower self-efficacy for PrEP use, while those with more positive descriptive norms reported higher self-efficacy for PrEP use. Attitudes, descriptive norms, and self-efficacy predicted intentions, B = 0.28 (0.13), p < .05, B = 0.32 (0.11), p < .01, and B = 0.17 (0.08), p < .05, respectively. Thus, those who felt more positively about PrEP themselves, those who thought friends and community members were more likely to use PrEP, and those with greater self-efficacy for PrEP use reported greater intentions to use PrEP. Neither knowledge nor subjective norms was associated with self-efficacy or intentions. Additionally, contrary to the IMB model, self-efficacy did not mediate the effects of knowledge, attitudes, stigma, descriptive norms, or subjective norms on intentions, although there were marginally significant indirect effects of stigma and descriptive norms on intentions via self-efficacy in the hypothesized directions (stigma: B = −0.03 [0.02], 95% CI = −0.08, 0.002, p < .10; descriptive norms: B = 0.05 [0.03], 95% CI = −0.002, 0.12, p < .10). IMB constructs and demographics explained 35% of the variance in intentions.
Associations between demographic controls and model constructs are shown in Table 3. To summarize, in the PrEP use model, participants who were Latino and unemployed had lower knowledge scores, while those with higher income knew more about PrEP. Latinos and unemployed individuals had more negative attitudes about PrEP. Those in monogamous relationships and unemployed individuals perceived more PrEP stigma, while those with higher income and students perceived less PrEP stigma. Those who were unemployed had more negative descriptive and subjective PrEP norms. Participants who were older and Black reported greater PrEP self-efficacy. Finally, accounting for other IMB constructs, participants who were Latino and Black were more likely to be using PrEP, while those in monogamous relationships were less likely to be using PrEP. Similar patterns were seen in the intentions model. In addition, participants who were Black had greater intentions to use PrEP, while those in monogamous relationships had lower intentions to use PrEP.
Table 3.
PrEP Use Model (HIV-negative men and transgender individuals who have sex with men, N = 357) | |||||||
---|---|---|---|---|---|---|---|
Knowledge | Attitudes | Stigma | Des. Norms | Sub. Norms | Self-Efficacy | Use | |
Age | 0.15 (0.06)* | −0.21 (0.13)+ | |||||
Latino | −0.46 (0.19)* | −0.54 (0.20)** | 0.83 (0.27)** | ||||
Black | 0.38 (0.18)* | 0.86 (0.25)*** | |||||
Multiracial | 0.47 (0.28)+ | ||||||
Transgender | −0.48 (0.25)+ | ||||||
Monogamous | 0.32 (0.12)* | −0.50 (0.25)* | |||||
Unemployed | −0.42 (0.20)* | −0.52 (0.24)* | 0.50 (0.20)* | −0.37 (0.21)+ | −0.57 (0.21)** | ||
Income | 0.09 (0.04)** | −0.09 (0.04)* | |||||
Lives in a City | −0.25 (0.14)+ | ||||||
Student | −0.29 (0.15)* | ||||||
PrEP Intentions Model (HIV-negative men and transgender individuals who have sex with men and are not currently taking PrEP, N = 310) | |||||||
Knowledge | Attitudes | Stigma | Des. Norms | Sub. Norms | Self-Efficacy | Intentions | |
Age | 0.17 (0.05)*** | ||||||
Latino | −0.64 (0.18)*** | −0.62 (0.19)*** | 0.36 (0.14)** | ||||
Black | 0.97 (0.18)*** | ||||||
Multiracial | 0.49 (0.23)* | ||||||
Transgender | |||||||
Monogamous | 0.27 (0.12)* | −0.46 (0.13)*** | −0.46 (0.13)*** | ||||
Unemployed | −0.47 (0.22)* | −0.56 (0.25)* | 0.41 (0.21)+ | −0.37 (0.18)* | −0.71 (0.25)** | ||
Income | −0.07 (0.03)* | ||||||
Lives in a City | 0.23 (0.13)+ | ||||||
Student |
* p < .05
** p < .01
*** p < .001
+ p < .10
Notes. Unstandardized linear and probit regression coefficients (for continuous and categorical outcomes, respectively) and standard errors from final structural equation models are reported. Age was divided by 10 for analyses, such that an increase of 1 in age is equivalent to 10 years. Income was assessed on a 6-point scale. PrEP = Pre-Exposure Prophylaxis; Des. Norms = Descriptive Norms; Sub. Norms = Subjective Norms.
DISCUSSION
New PrEP-related measures were successfully piloted with a diverse sample of MSM and transgender individuals. Results suggested that the IMB model is applicable to PrEP use among MSM, with knowledge, attitudes, stigma, descriptive norms, and self-efficacy all playing roles. The IMB model and these new measures may be useful when developing and assessing interventions to increase PrEP uptake.
In our sample from a community event in a midsized Midwestern city, relatively few participants (12%) were currently using PrEP. Research has suggested that PrEP uptake has been slower outside of major coastal cities (73, 74). Investigating correlates of use and intentions among men and transgender individuals in these areas may be particularly important.
In line with the IMB model, information (PrEP knowledge); motivation (PrEP attitudes, PrEP stigma, and PrEP descriptive norms); and behavioral skills (PrEP self-efficacy) all had associations with PrEP use. PrEP knowledge was directly associated with PrEP use. Notably, a number of studies focused on condom use have not found associations between information (knowledge) and behavior (20, 75–79), leading investigators to posit that information may not be as central as theorized by the IMB model. However, it is possible that when focusing on a behavior where many individuals know very little, such as PrEP use, gaining a base level of knowledge may be essential. Research has suggested that many primary care doctors depend on patients to initiate conversations about PrEP (80); therefore, MSM and transgender individuals may need at least a basic understanding of PrEP to effectively broach the topic with their providers. Some previous research has suggested that MSM of color may be less aware of and less knowledgeable about PrEP (81–83). In our study, Latino MSM were less knowledgeable than White and Black MSM about PrEP, while multiracial MSM knew more about PrEP. Thus, in this Midwestern city, or at least among those attending this particular community event, educational efforts and health campaigns may be succeeding in reaching Black and multiracial men, but not Latino men. Notably, PrEP knowledge was low overall, with the average participant answering less than half of the knowledge questions correctly. Increasing PrEP awareness and knowledge among MSM in general, and among Black and Latino MSM in particular, may be key to increasing PrEP uptake among those most at risk of HIV.
Multiple motivational constructs were associated with both use and intentions. As hypothesized by the IMB model, PrEP attitudes, stigma, and descriptive norms all had indirect effects on PrEP use via PrEP self-efficacy; PrEP stigma also had a direct association with use. PrEP attitudes and descriptive norms both also had direct associations with PrEP intentions. Research in other domains of sexual health, including condom use, HIV testing, and adherence to HIV antiretrovirals, has long supported the importance of motivation to intentions and behavior (19, 84–89). Past qualitative research with MSM and transgender women has suggested that PrEP stigma (e.g., labeling PrEP users as “Truvada whores,” 90) is quite common, and that this stigma is an impediment to PrEP uptake (38–45). Our research shows quantitative associations between PrEP stigma and use in line with the IMB model, and suggests that stigma may contribute to use beyond knowledge, attitudes, norms, and self-efficacy. The associations between PrEP descriptive norms and self-efficacy and intentions suggest that public health campaigns focused on making MSM aware of PrEP use by others in their community may be effective. By encouraging individuals to talk to others they know about PrEP, the CDC’s “Talk PrEP” campaign capitalizes on this approach (91). Interestingly, although all other motivational constructs had associations with self-efficacy, intentions, or use, when testing the full IMB model, PrEP subjective norms were not associated with any of the three, despite having positive bivariate correlations with self-efficacy (r = .38, p < .001) and intentions (r = .34, p < .001) in preliminary analyses. This suggests that participants’ impressions of others’ attitudes toward PrEP use may be less important than participants’ own attitudes, perceptions of stigma, and ideas about others’ behaviors.
Finally, as expected, self-efficacy for PrEP use was positively associated with both PrEP use and PrEP intentions. Our measure of PrEP self-efficacy assessed a variety of behaviors involved in receiving a prescription for PrEP and taking PrEP, finding that participants perceived some to be quite easy (e.g., getting tested for HIV, which 57% said would be “very easy to do”) and others to be more difficult (e.g., finding a way to pay for PrEP, which only 25% said would be “very easy to do”). These findings are in line with prior research suggesting that the cost of PrEP (37, 39, 92, 93) and lack of insurance (45, 92, 94) are barriers to PrEP use. Interestingly, while some prior studies have suggested that MSM may be uncomfortable talking with health care providers about sexual behavior, sexual orientation, and PrEP (95–97), participants in our sample felt it would be relatively easy to discuss sexual behaviors with their doctors (45% said this would be “very easy” and 31% “somewhat easy”). The positive associations between PrEP self-efficacy and behavior are in line with research focused on other HIV prevention behaviors, such as condom use, HIV testing, and adherence to HIV antiretrovirals (84, 88, 98–100). These findings are also consistent with those of Shrestha et al. (2017), who found in a test of the IMB model with PWUD at higher risk that behavioral skills were positively associated with PrEP willingness (36). Including skills components in interventions may help increase PrEP self-efficacy and overcome obstacles to initiating PrEP use.
Although this study is one of the first that we know of to develop multiple IMB-related measures for PrEP use and to test the IMB model for PrEP use in a sample of MSM and transgender individuals, there are several limitations to consider. First, the cross-sectional nature of our research precludes us from determining cause and effect. It is possible, for example, that individuals learn more about PrEP in the process of beginning to take it, or that using PrEP reduces perceptions of PrEP stigma. Future research using longitudinal data is needed. Second, our participants were recruited at one community event. Though our sample was diverse in in terms of age, race/ethnicity, and income, our new PrEP measures and the IMB model for PrEP use should be tested among men recruited from other settings and from other geographic locations. Third, our new measures performed well and captured many of the constructs commonly included in the IMB model; however, there are additional predictors that fit within the IMB model that could be considered in future research. For example, risk perceptions are another dimension of motivation and should be tested as a predictor of PrEP use. Additionally, information, attitudes, stigma, or social norms about HIV or HIV prevention in general or other forms of HIV prevention (e.g., condom use) may influence PrEP outcomes; future research could consider this possibility. As qualitative and quantitative researchers continue to increase our understanding of factors influencing PrEP use, these new PrEP-related scales may need to incorporate additional items: for example, it is possible that self-efficacy for PrEP use may also involve overcoming partner obstacles. Finally, although the IMB model is well-supported by past research (22–24), there are limitations to the model itself, and other constructs not considered in this model may be important predictors of PrEP use. For example, researchers have identified structural barriers not explicitly acknowledged by the IMB model (such as issues with access to care and insurance) as potential influences PrEP use (45, 92, 94). Incorporating constructs from other theories of health behavior in addition to the IMB model may lead to stronger interventions.
In conclusion, we found support for new measures of PrEP-related constructs, including knowledge, attitudes, stigma, descriptive and subjective norms, self-efficacy, and intentions. These measures may be useful for future research. Additionally, this research provides preliminary evidence that the IMB model constructs may present reasonable targets for future intervention programs aiming to increase PrEP uptake. Effective intervention programs to increase PrEP uptake will be essential to reducing disparities in PrEP use and HIV prevalence.
Supplementary Material
Acknowledgements:
The author thanks Michelle Broaddus, Andrew Petroll, and Katherine Quinn for their contributions to measure development.
Funding: This study was funded by National Institutes of Health grants 5P30-MH052776 and K01-MH099956.
Appendix: Full PrEP Measures
Measure | Items | α | Sample Item | Scale |
---|---|---|---|---|
PrEP Knowledge | 13 | .90 | “You should not use PrEP if you don’t know your HIV status.” | True/False/Don’t Know |
PrEP Attitudes | 5 | .79 | “Taking PrEP is safe.” | 1=Strongly Disagree to 5=Strongly Agree |
PrEP Stigma | 5 | .83 | “People who take PrEP are promiscuous.” | 1=Strongly Disagree to 5=Strongly Agree |
PrEP Descriptive Norms | 6 | .93 | “People in my community would consider taking PrEP.” | 1=Strongly Disagree to 5=Strongly Agree |
PrEP Subjective Norms | 6 | .94 | “My friends would think it was responsible if I used PrEP.” | 1=Strongly Disagree to 5=Strongly Agree |
Efficacy | 8 | .87 | “How difficult would it be for you to visit a doctor who can provide PrEP?” | 1=Very Hard to Do to 4=Very Easy to Do |
PrEP Intentions | 3 | .90 | “During the next three months, I will get a prescription for PrEP.” | 1=Definitely Will Not Do to 4=Definitely Will Do |
PrEP Knowledge
For each of the following questions, please choose True (T), False (F), or Don’t Know (DK). If you do not know, please do not guess; instead, please choose Don’t Know. | ||||
---|---|---|---|---|
A. | PrEP is a daily pill you can take to reduce your risk of becoming infected with HIV. | T | F | DK |
B. | You should not use PrEP if you don’t know your HIV status. | T | F | DK |
C. | If you do not take PrEP consistently, there may not be enough medicine in your bloodstream to block the HIV virus. | T | F | DK |
D. | PrEP can be used to prevent STIs like gonorrhea, chlamydia, syphilis, herpes, and HPV. | T | F | DK |
E. | Many insurance plans will cover PrEP. | T | F | DK |
F. | If you start taking PrEP, you will have to take it for the rest of your life. | T | F | DK |
G. | PrEP can be taken by people who already have HIV. | T | F | DK |
H. | There are ways to get PrEP even if you do not have insurance. | T | F | DK |
I. | PrEP is available over-the-counter. | T | F | DK |
J. | You must take an HIV test every 3 months while taking PrEP. | T | F | DK |
K. | There are many serious side effects of taking PrEP. | T | F | DK |
L. | The PrEP pill contains two medicines that are also used to treat HIV. | T | F | DK |
M. | Daily PrEP use can lower the risk of getting HIV from sex by more than 90%. | T | F | DK |
PrEP Attitudes
Do you agree or disagree with the following statements? | ||||||
---|---|---|---|---|---|---|
Strongly Disagree |
Disagree | Neutral | Agree | Strongly Agree |
||
A. | PrEP is effective at preventing HIV. | 1 | 2 | 3 | 4 | 5 |
B. | People who take PrEP are responsible. | 1 | 2 | 3 | 4 | 5 |
C. | Taking PrEP is safe. | 1 | 2 | 3 | 4 | 5 |
D. | It would be no trouble to take PrEP every day. | 1 | 2 | 3 | 4 | 5 |
E. | The government makes certain that drugs like PrEP are safe. | 1 | 2 | 3 | 4 | 5 |
PrEP Stigma
Do you agree or disagree with the following statements? | ||||||
---|---|---|---|---|---|---|
Strongly Disagree | Disagree | Neutral | Agree | Strongly Agree | ||
A. | People who take PrEP are promiscuous. | 1 | 2 | 3 | 4 | 5 |
B. | Getting a PrEP prescription from a doctor would be embarrassing. | 1 | 2 | 3 | 4 | 5 |
C. | If I were to take PrEP, I would be concerned if my friends found out I was taking it. | 1 | 2 | 3 | 4 | 5 |
D. | If I were to take PrEP, I would be concerned if my family found out I was taking it. | 1 | 2 | 3 | 4 | 5 |
E. | If I were to take PrEP, I would be concerned if my sexual partner(s) found out I was taking it. | 1 | 2 | 3 | 4 | 5 |
PrEP Subjective Norms
Do you agree or disagree with the following statements? | |||||||
Strongly Disagree | Disagree | Neutral | Agree | Strongly Agree | |||
A. | My friends would be supportive of me using PrEP. | 1 | 2 | 3 | 4 | 5 | |
B. | My friends would think it was smart if I used PrEP. | 1 | 2 | 3 | 4 | 5 | |
C. | My friends would think it was responsible if I used PrEP. | 1 | 2 | 3 | 4 | 5 | |
D. | My sexual partner(s) would be supportive of me using PrEP. | 1 | 2 | 3 | 4 | 5 | |
E. | My sexual partner(s) would think it was smart if I used PrEP. | 1 | 2 | 3 | 4 | 5 | |
F. | My sexual partner(s) would think it was responsible if I used PrEP. | 1 | 2 | 3 | 4 | 5 |
(Items A, B, C form “friends” subscale; items D, E, F form “sexual partner” subscale. These subscales can also be combined into a general subjective norms scale.)
PrEP Descriptive Norms
Do you agree or disagree with the following statements? | |||||||
Strongly Disagree | Disagree | Neutral | Agree | Strongly Agree | |||
A. | People in my community would be interested in learning more about PrEP. | 1 | 2 | 3 | 4 | 5 | |
B. | People in my community would be willing to talk with their doctors about using PrEP. | 1 | 2 | 3 | 4 | 5 | |
C. | People in my community would consider taking PrEP. | 1 | 2 | 3 | 4 | 5 | |
D. | My friends would be interested in learning more about PrEP. | 1 | 2 | 3 | 4 | 5 | |
E. | My friends would be willing to talk with their doctors about using PrEP. | 1 | 2 | 3 | 4 | 5 | |
F. | My friends would consider taking PrEP. | 1 | 2 | 3 | 4 | 5 |
(Items A, B, C form “community” subscale; items D, E, F form “friends” subscale. These subscales can also be combined into a general descriptive norms scale.)
PrEP Self-Efficacy
How difficult or easy would the following be? | ||||||
Very Hard to Do | Somewhat Hard to Do | Somewhat Easy to Do | Very Easy to Do | |||
A. | How difficult would it be for you to seek out more information about PrEP to decide if it is right for you? | 1 | 2 | 3 | 4 | |
B. | People in my community would be willing to talk with their doctors about using PrEP. | 1 | 2 | 3 | 4 | |
C. | People in my community would consider taking PrEP. | 1 | 2 | 3 | 4 | |
D. | My friends would be interested in learning more about PrEP. | 1 | 2 | 3 | 4 | |
E. | My friends would be willing to talk with their doctors about using PrEP. | 1 | 2 | 3 | 4 | |
F. | My friends would consider taking PrEP. | 1 | 2 | 3 | 4 | |
G. | How difficult would it be for you take a medicine like PrEP every day? | 1 | 2 | 3 | 4 | |
H. | How difficult would it be for you to visit a doctor every three months for routine screenings? | 1 | 2 | 3 | 4 |
PrEP Intentions
How likely are you to do the following?
Definitely Will Not Do | Probably Will Not Do | Probably Will Do | Definitely Will Do | ||
A. | During the next three months, I will talk to a health care provider about PrEP. | 1 | 2 | 3 | 4 |
B. | During the next three months, I will seek out more information about PrEP. | 1 | 2 | 3 | 4 |
C. | During the next three months, I will get a prescription for PrEP. | 1 | 2 | 3 | 4 |
Footnotes
Compliance with Ethical Standards:
Conflict of Interest: Jennifer L. Walsh declares that she has no conflict of interest.
Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent: The data collected in this study were fully anonymous. Due to the low-risk nature of the study, participants received an informational letter describing the study, and completion of the survey constituted consent.
REFERENCES
- 1.Prejean J, Song R, Hernandez A, Ziebell R, Green T, Walker F, et al. Estimated HIV incidence in the United States, 2006–2009. PLoS One 2011;6(8):e17502. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Centers for Disease Control and Prevention. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 US dependent areas—2010. HIV Surveillance Supplemental Report 2012;17(3). [Google Scholar]
- 3.Thigpen MC, Kebaabetswe PM, Paxton LA, Smith DK, Rose CE, Segolodi TM, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med 2012;367(5):423–34. [DOI] [PubMed] [Google Scholar]
- 4.Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 2012;367(5):399–410. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men. New Engl J Med 2010;363(27):2587–99. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Molina J-M, Capitant C, Spire B, Pialoux G, Chidiac C, Charreau I. On demand PrEP with oral TDF-FTC in MSM: Results of the ANRS Ipergay trial. Conference on Retroviruses and Opportunistic Infections; Seattle, WA: 2015. p. 23–6. [Google Scholar]
- 7.McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet 2016;387(10013):53–60. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Donnell D, Baeten JM, Bumpus NN, Brantley J, Bangsberg DR, Haberer JE, et al. HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention. J Acquir Immune Defic Syndr 2014;66(3):340–8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Anderson PL, Glidden DV, Liu A, Buchbinder S, Lama JR, Guanira JV, et al. Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. Sci Transl Med 2012;4(151):151ra25. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Grant RM, Anderson PL, McMahan V, Liu A, Amico KR, Mehrotra M, et al. Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis 2014;14(9):820–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Laufer FN, O’Connell DA, Feldman I, Zucker HA. Vital Signs: Increased Medicaid Prescriptions for Preexposure Prophylaxis Against HIV infection—New York, 2012–2015. Morbidity and Mortality Weekly Report 2015;64(46):1296–301. [DOI] [PubMed] [Google Scholar]
- 12.Bush S, Ng L, Magnuson D, Piontkowsky D, Mera Giler R, editors. Significant uptake of Truvada for pre-exposure prophylaxis (PrEP) utilization in the US in late 2014–1Q 2015. IAPAC Treatment, Prevention, and Adherence Conference; 2015. [Google Scholar]
- 13.Scanlin K, Salcuni P, Edelstein Z, Daskalakis D, Mensah N, Tsoi B, et al. , editors. Increasing PrEP use among Men Who Have Sex With Men, New York City 2013–2015. Conference on Retroviruses and opportunistic infections February; 2016. [Google Scholar]
- 14.Delaney K, Sanchez T, Bowles K, Oraka E, DiNenno E, Sullivan P, editors. Awareness and use of PrEP appear to be increasing among internet samples of US MSM. Conference on Retroviruses and Opportunistic Infections; 2016. [Google Scholar]
- 15.Hood JE, Buskin SE, Dombrowski JC, Kern DA, Barash EA, Katzi DA, et al. Dramatic increase in preexposure prophylaxis use among MSM in Washington state. Aids 2016;30(3):515–9. [DOI] [PubMed] [Google Scholar]
- 16.Grant R, Liu A, Hecht J, Buchbinder S, Weber S, Crouch P. Scale-up of preesposure prophylaxis in San Francisco to impact HIV incidence Conference on Retroviruses and Opportunistic Infections; Seattle, WA: 2015. [Google Scholar]
- 17.Smith DK, Van Handel M, Wolitski RJ, Stryker JE, Hall HI, Prejean J, et al. Vital Signs: Estimated Percentages and Numbers of Adults with Indications for Preexposure Prophylaxis to Prevent HIV Acquisition -United States, 2015. Mmwr-Morbid Mortal W 2015;64(46):1291–5. [DOI] [PubMed] [Google Scholar]
- 18.Siegler AJ, Mouhanna F, Giler RM, McCallister S, Yeung H, Jones J, et al. Distribution of active PrEP prescriptions and the PrEP-to-need ratio, US, Q2 2017 25th Conference on Retroviruses and Opportunistic Infections (CROI 2018); Boston: 2018. [Google Scholar]
- 19.Fisher JD, Fisher WA. Changing AIDS-risk behavior. Psychological bulletin 1992;111(3):455–74. [DOI] [PubMed] [Google Scholar]
- 20.Fisher JD, Fisher WA, Shuper PA. The information-motivation-behavioral skills model of HIV preventive behavior. Emerging theories in health promotion practice and research 2009;2:21–64. [Google Scholar]
- 21.Johnson BT, Redding CA, DiClemente RJ, Mustanski BS, Dodge B, Sheeran P, et al. A network-individual-resource model for HIV prevention. AIDS Behav 2010;14(Suppl 2):204–21. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 22.Fisher JD, Fisher WA, Amico KR, Harman JJ. An information-motivation-behavioral skills model of adherence to antiretroviral therapy. Health Psychol 2006;25(4):462–73. [DOI] [PubMed] [Google Scholar]
- 23.Fisher WA, Fisher JD, Harman J. The Information-Motivation-Behavioral Skills Model: A general social psychological approach to understanding and promoting health behavior Social Psychological Foundations of Health and Illness: Blackwell Publishing Ltd; 2009. p. 82–106. [Google Scholar]
- 24.Fisher WA, Fisher JD, Harman J. The information-motivation-behavioral skills model: A general social psychological approach to understanding and promoting health behavior. Social Psychological Foundations of Health and Illness 2003:82–106. [Google Scholar]
- 25.Dubov A, Altice FL, Fraenkel L. An Information-Motivation-Behavioral Skills Model of PrEP Uptake. AIDS Behav 2018. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26.Krakower DS, Mimiaga MJ, Rosenberger JG, Novak DS, Mitty JA, White JM, et al. Limited Awareness and Low Immediate Uptake of Pre-Exposure Prophylaxis among Men Who Have Sex with Men Using an Internet Social Networking Site. PLoS One 2012;7(3):e33119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Garnett M, Hirsch-Moverman Y, Franks J, Hayes-Larson E, El-Sadr WM, Mannheimer S. Limited awareness of pre-exposure prophylaxis among black men who have sex with men and transgender women in New York city. AIDS care 2018;30(1):9–17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28.Bauermeister JA, Meanley S, Pingel E, Soler JH, Harper GW. PrEP awareness and perceived barriers among single young men who have sex with men. Current HIV research 2013;11(7):520–7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29.Goedel WC, Halkitis PN, Greene RE, Duncan DT. Correlates of Awareness of and Willingness to Use Pre-exposure Prophylaxis (PrEP) in Gay, Bisexual, and Other Men Who Have Sex with Men Who Use Geosocial-Networking Smartphone Applications in New York City. AIDS Behav 2016;20(7):1435–42. [DOI] [PubMed] [Google Scholar]
- 30.Dolezal C, Frasca T, Giguere R, Ibitoye M, Cranston RD, Febo I, et al. Awareness of Post-Exposure Prophylaxis (PEP) and Pre-Exposure Prophylaxis (PrEP) Is Low but Interest Is High Among Men Engaging in Condomless Anal Sex With Men in Boston, Pittsburgh, and San Juan. AIDS education and prevention : official publication of the International Society for AIDS Education 2015;27(4):289–97. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 31.Eaton LA, Driffin DD, Bauermeister J, Smith H, Conway-Washington C. Minimal Awareness and Stalled Uptake of Pre-Exposure Prophylaxis (PrEP) Among at Risk, HIV-Negative, Black Men Who Have Sex with Men. AIDS patient care and STDs 2015;29(8):423–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32.Mosley T, Khaketla M, Armstrong HL, Cui Z, Sereda P, Lachowsky NJ, et al. Trends in Awareness and Use of HIV PrEP Among Gay, Bisexual, and Other Men who have Sex with Men in Vancouver, Canada 2012–2016. AIDS and Behavior 2018:1–16. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33.Krotchko J, editor Changes in Awareness of Human Immunodeficiency Virus (HIV) Pre-exposure Prophylaxis (PrEP) in High-Risk Populations of Men Who Have Sex With Men (MSM) in Denver Colorado in 2008, 2011, and 2014: Implications for Implementation Open Forum Infectious Diseases; 2016: Oxford University Press. [Google Scholar]
- 34.AIDSVu: Emory University, Rollins School of Public Health; 2018. [Available from: https://map.aidsvu.org/map?prep=1.
- 35.Salcuni P, Smolen J, Jain S, Myers J, Edelstein Z. Trends and Associations with PrEP Prescription Among 602 New York City (NYC) Ambulatory Care Practices, 2014–2016. Open Forum Infectious Diseases 2017;4(Suppl 1):S21–S. [Google Scholar]
- 36.Shrestha R, Altice FL, Huedo-Medina TB, Karki P, Copenhaver M. Willingness to Use Pre-Exposure Prophylaxis (PrEP): An Empirical Test of the Information-Motivation-Behavioral Skills (IMB) Model among High-Risk Drug Users in Treatment. AIDS and Behavior 2017;21(5):1299–308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 37.King HL, Keller SB, Giancola MA, Rodriguez DA, Chau JJ, Young JA, et al. Pre-exposure prophylaxis accessibility research and evaluation (PrEPARE Study). AIDS Behav 2014;18(9):1722–5. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 38.Liu A, Cohen S, Follansbee S, Cohan D, Weber S, Sachdev D, et al. Early experiences implementing pre-exposure prophylaxis (PrEP) for HIV prevention in San Francisco. PLoS medicine 2014;11(3):e1001613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 39.Biello KB, Oldenburg CE, Mitty JA, Closson EF, Mayer KH, Safren SA, et al. The “Safe Sex” Conundrum: Anticipated Stigma From Sexual Partners as a Barrier to PrEP Use Among Substance Using MSM Engaging in Transactional Sex. AIDS Behav 2017;21(1):300–6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 40.Oldenburg CE, Mitty JA, Biello KB, Closson EF, Safren SA, Mayer KH, et al. Differences in Attitudes About HIV Pre-Exposure Prophylaxis Use Among Stimulant Versus Alcohol Using Men Who Have Sex with Men. AIDS Behav 2016;20(7):1451–60. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 41.Oldenburg CE, Perez-Brumer AG, Hatzenbuehler M, Krakower DS, Novak DS, Mimiaga MJ, et al. Structural stigma affects access to pre-and post-exposure prophylaxis and HIV risk among men who have sex with men (MSM) in the United States 2014. [Google Scholar]
- 42.Perez-Figueroa RE, Kapadia F, Barton SC, Eddy JA, Halkitis PN. Acceptability of PrEP uptake among racially/ethnically diverse young men who have sex with men: The P18 study. AIDS Educ Prev 2015;27(2):112–25. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 43.Garcia J, Parker C, Parker RG, Wilson PA, Philbin M, Hirsch JS. Psychosocial implications of homophobia and HIV stigma in social support networks: Insights for high-impact HIV prevention among Black men who have sex with men. Health Educ Behav 2016;43(2):217–25. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 44.Van der Elst EM, Mbogua J, Operario D, Mutua G, Kuo C, Mugo P, et al. High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: Qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya. AIDS Behav 2013;17(6):2162–72. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 45.Philbin MM, Parker CM, Parker RG, Wilson PA, Garcia J, Hirsch JS. The promise of pre-exposure prophylaxis for Black men who have sex with men: An ecological approach to attitudes, beliefs, and barriers. AIDS Patient Care STDS 2016;30(6):282–90. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 46.Zarwell M, Payne N, Robinson W, editors. Usage and perceptions of PrEP among men who have sex with men (MSM) in New Orleans, 2014 143rd APHA Annual Meeting and Exposition, Chicago, IL; 2015. [Google Scholar]
- 47.Mantell JE, Sandfort TG, Hoffman S, Guidry JA, Masvawure TB, Cahill S. Knowledge and Attitudes about Pre-Exposure Prophylaxis (PrEP) among Sexually Active Men Who Have Sex with Men (MSM) Participating in New York City Gay Pride Events. LGBT health 2014;1(2):93–7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 48.Koechlin FM, Fonner VA, Dalglish SL, O’Reilly KR, Baggaley R, Grant RM, et al. Values and Preferences on the Use of Oral Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Multiple Populations: A Systematic Review of the Literature. AIDS Behav 2017;21(5):1325–35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49.Smith DK, Toledo L, Smith DJ, Adams MA, Rothenberg R. Attitudes and program preferences of African-American urban young adults about pre-exposure prophylaxis (PrEP). AIDS Education and Prevention 2012;24(5):408–21. [DOI] [PubMed] [Google Scholar]
- 50.Galindo GR, Walker JJ, Hazelton P, Lane T, Steward WT, Morin SF, et al. Community member perspectives from transgender women and men who have sex with men on pre-exposure prophylaxis as an HIV prevention strategy: implications for implementation. Implementation science : IS 2012;7:116. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 51.Brooks RA, Landovitz RJ, Regan R, Lee SJ, Allen VC Jr. Perceptions of and intentions to adopt HIV pre-exposure prophylaxis among black men who have sex with men in Los Angeles. International journal of STD & AIDS 2015;26(14):1040–8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 52.Golub SA, Gamarel KE, Rendina HJ, Surace A, Lelutiu-Weinberger CL. From efficacy to effectiveness: facilitators and barriers to PrEP acceptability and motivations for adherence among MSM and transgender women in New York City. AIDS patient care and STDs 2013;27(4):248–54. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 53.Carey MP, Morrison-Beedy D, Johnson BT. The HIV-Knowledge Questionnaire: Development and evaluation of a reliable, valid, and practical self-administered questionnaire. AIDS and Behavior 1997;1(1):61–74. [Google Scholar]
- 54.Helweg-Larsen M, Collins BE. The UCLA Multidimensional Condom Attitudes Scale: documenting the complex determinants of condom use in college students. Health Psychol 1994;13(3):224–37. [DOI] [PubMed] [Google Scholar]
- 55.Fisher TD, Davis CM, Yarber WL, Davis SL. Handbook of sexuality-related measures: Routledge; 2013. [Google Scholar]
- 56.Brown IS. Development of a scale to measure attitude toward the condom as a method of birth control. Journal of Sex Research 1984;20(3):255–63. [Google Scholar]
- 57.St Lawrence JS, Reitman D, Jefferson KW, Alleyne E, Brasfield TL, Shirley A. Factor structure and validation of an adolescent version of the Condom Attitude Scale: An instrument for measuring adolescents’ attitudes toward condoms. Psychological Assessment 1994;6(4):352. [Google Scholar]
- 58.Donenberg GR, Schwartz RM, Emerson E, Wilson HW, Bryant FB, Coleman G. Applying a cognitive-behavioral model of HIV risk to youths in psychiatric care. AIDS education and prevention : official publication of the International Society for AIDS Education 2005;17(3):200–16. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 59.Carey MP, Braaten LS, Maisto SA, Gleason JR, Forsyth AD, Durant LE, et al. Using information, motivational enhancement, and skills training to reduce the risk of HIV infection for low-income urban women: a second randomized clinical trial. Health Psychol 2000;19(1):3–11. [DOI] [PubMed] [Google Scholar]
- 60.O’Leary A, Jemmott LS, Jemmott JB. Mediation analysis of an effective sexual risk-reduction intervention for women: the importance of self-efficacy. Health Psychol 2008;27(2s):S180–4. [DOI] [PubMed] [Google Scholar]
- 61.Carey MP, Senn TE, Walsh JL, Coury-Doniger P, Urban MA, Fortune T, et al. Evaluating a Brief, Video-Based Sexual Risk Reduction Intervention and Assessment Reactivity with STI Clinic Patients: Results from a Randomized Controlled Trial. AIDS Behav 2015;19(7):1228–46. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 62.Rocca CH, Harper CC. Do racial and ethnic differences in contraceptive attitudes and knowledge explain disparities in method use? Perspectives on sexual and reproductive health 2012;44(3):150–8. [DOI] [PubMed] [Google Scholar]
- 63.Graham JW, Taylor BJ, Olchowski AE, Cumsille PE. Planned missing data designs in psychological research. Psychological Methods 2006;11(4):323–43. [DOI] [PubMed] [Google Scholar]
- 64.Schafer JL. Multiple imputation: A primer. Statistical Methods in Medical Research 1999;8(1):3–15. [DOI] [PubMed] [Google Scholar]
- 65.Clark LA, Watson D. Constructing validity: Basic issues in objective scale development. Psychological assessment 1995;7(3):309. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 66.Kline RB. Principles and practice of structural equation modeling: Guilford press; 2011. [Google Scholar]
- 67.Lt Hu, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equ Modeling 1999;6(1):1–55. [Google Scholar]
- 68.Zedeck S APA dictionary of statistics and research methods: American Psychological Association; Washington, DC; 2014. [Google Scholar]
- 69.Bauer DJ. A more general model for testing measurement invariance and differential item functioning. Psychol Methods 2017;22(3):507–26. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 70.Little TD, Cunningham WA, Shahar G, Widaman KF. To parcel or not to parcel: Exploring the question, weighing the merits. Struct Equ Modeling 2002;9(2):151–73. [Google Scholar]
- 71.Muthén LK, Muthén BO. Mplus user’s guide 7 ed. Los Angeles: Muthén & Muthén; [Google Scholar]
- 72.Tofighi D, MacKinnon DP. RMediation: An R package for mediation analysis confidence intervals. Behavior Research Methods 2011;43(3):692–700. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 73.Hoots BE, Finlayson T, Nerlander L, Paz-Bailey G. Willingness to Take, Use of, and Indications for Pre-exposure Prophylaxis Among Men Who Have Sex With Men-20 US Cities, 2014. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016;63(5):672–7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 74.Mera R, McCallister S, Palmer B, Mayer G, Magnuson D, Rawlings M. FTC/TDF (Truvada) for HIV pre-exposure prophylaxis (PrEP) utilization in the United States: 2012–2015 Foster City, CA, USA: 2016. [Google Scholar]
- 75.Fisher JD, Fisher WA, Williams SS, Malloy TE. Empirical tests of an information-motivation-behavioral skills model of AIDS-preventive behavior with gay men and heterosexual university students. Health Psychology 1994;13(3):238. [DOI] [PubMed] [Google Scholar]
- 76.Kalichman SC, Picciano JF, Roffman RA. Motivation to reduce HIV risk behaviors in the context of the information, motivation and behavioral skills (IMB) model of HIV prevention. Journal of Health Psychology 2008;13(5):680–9. [DOI] [PubMed] [Google Scholar]
- 77.Mustanski B, Donenberg G, Emerson E. I can use a condom, I just don’t: The importance of motivation to prevent HIV in adolescent seeking psychiatric care. AIDS and Behavior 2006;10(6):753–62. [DOI] [PubMed] [Google Scholar]
- 78.Robertson AA, Stein JA, Baird-Thomas C. Gender differences in the prediction of condom use among incarcerated juvenile offenders: testing the information-motivation-behavior skills (IMB) model. Journal of Adolescent Health 2006;38(1):18–25. [DOI] [PubMed] [Google Scholar]
- 79.Walsh JL, Senn TE, Scott-Sheldon LA, Vanable PA, Carey MP. Predicting condom use using the Information-Motivation-Behavioral Skills (IMB) model: a multivariate latent growth curve analysis. Annals of Behavioral Medicine 2011;42(2):235. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 80.Petroll AE, Walsh JL, Owczarzak JL, McAuliffe TL, Bogart LM, Kelly JA. PrEP awareness, familiarity, comfort, and prescribing experience among US primary care providers and HIV specialists. AIDS and Behavior 2017;21(5):1256–67. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 81.Raifman JR, Flynn C, German D. Healthcare Provider Contact and Pre-exposure Prophylaxis in Baltimore Men Who Have Sex With Men. Am J Prev Med 2017;52(1):55–63. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 82.Pulsipher C, Montoya J, Plant A, Curtis P, Holloway I, Leibowitz A. Addressing PrEP Disparities among Young Gay and Bisexual Men in California California HIV/AIDS Policy Research Centers, California: 2016. [Google Scholar]
- 83.Bogorodskaya M, Avery A. Favorable Attitudes but Low Awareness and Restricted Access to Pre-exposure Prophylaxis (PrEP) Against Human Immunodeficiency Virus (HIV) in an Urban Midwestern Community. Open Forum Infectious Diseases 2016;3(suppl_1):506-. [Google Scholar]
- 84.Sheeran P, Abraham C, Orbell S. Psychosocial correlates of heterosexual condom use: a meta-analysis. Psychological bulletin 1999;125(1):90–132. [DOI] [PubMed] [Google Scholar]
- 85.Kalichman SC, Simbayi LC. HIV testing attitudes, AIDS stigma, and voluntary HIV counselling and testing in a black township in Cape Town, South Africa. Sexually transmitted infections 2003;79(6):442–7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 86.Fortenberry JD, McFarlane M, Bleakley A, Bull S, Fishbein M, Grimley DM, et al. Relationships of stigma and shame to gonorrhea and HIV screening. Am J Public Health 2002;92(3):378–81. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 87.Kellerman SE, Lehman JS, Lansky A, Stevens MR, Hecht FM, Bindman AB, et al. HIV testing within at-risk populations in the United States and the reasons for seeking or avoiding HIV testing. J Acquir Immune Defic Syndr 2002;31(2):202–10. [DOI] [PubMed] [Google Scholar]
- 88.Amico KR, Toro-Alfonso J, Fisher JD. An empirical test of the information, motivation and behavioral skills model of antiretroviral therapy adherence. AIDS care 2005;17(6):661–73. [DOI] [PubMed] [Google Scholar]
- 89.Starace F, Massa A, Amico KR, Fisher JD. Adherence to antiretroviral therapy: an empirical test of the information-motivation-behavioral skills model. Health Psychol 2006;25(2):153–62. [DOI] [PubMed] [Google Scholar]
- 90.Calabrese SK, Underhill K. How stigma surrounding the use of HIV preexposure prophylaxis undermines prevention and pleasure: a call to destigmatize “truvada whores”. American journal of public health 2015;105(10):1960–4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 91.Centers for Disease Control and Prevention. Talk PrEP Atlanta: CDC; 2017. [updated 5/22/17. Available from: https://www.cdc.gov/actagainstaids/campaigns/starttalking/prep.html. [Google Scholar]
- 92.Strauss BB, Greene GJ, Phillips G 2nd, Bhatia R, Madkins K, Parsons JT, et al. Exploring patterns of awareness and use of HIV pre-exposure prophylaxis among young men who have sex with men. AIDS Behav 2016;21(5):1288–98. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 93.Chan PA, Mena L, Patel R, Oldenburg CE, Beauchamps L, Perez-Brumer AG, et al. Retention in care outcomes for HIV pre-exposure prophylaxis implementation programmes among men who have sex with men in three US cities. J Int AIDS Soc 2016;19(1):20903. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 94.Underhill K, Morrow KM, Colleran CM, Holcomb R, Operario D, Calabrese SK, et al. Access to healthcare, HIV/STI testing, and preferred pre-exposure prophylaxis providers among men who have sex with men and men who engage in street-based sex work in the US. PLoS One 2014;9(11):e112425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 95.Maloney KM, Krakower DS, Ziobro D, Rosenberger JG, Novak D, Mayer KH. Culturally Competent Sexual Healthcare as a Prerequisite for Obtaining Preexposure Prophylaxis: Findings from a Qualitative Study. LGBT health 2017;4(4):310–4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 96.Eaton LA, Driffin DD, Smith H, Conway-Washington C, White D, Cherry C. Psychosocial factors related to willingness to use pre-exposure prophylaxis for HIV prevention among Black men who have sex with men attending a community event. Sexual health 2014;11(3):244–51. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 97.Krakower D, Oldenburg C, Mimiaga M Novak D, Rosenberger J, Elsesser S, et al. , editors. Patient-provider communication about sexual behaviors and preexposure prophylaxis: results from a national online survey of men who have sex with men in the United States Poster presented at the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment & Prevention, Vancouver, British Columbia, Canada; 2015. [Google Scholar]
- 98.Berendes S, Rimal RN. Addressing the slow uptake of HIV testing in Malawi: the role of stigma, self-efficacy, and knowledge in the Malawi BRIDGE Project. The Journal of the Association of Nurses in AIDS Care : JANAC 2011;22(3):215–28. [DOI] [PubMed] [Google Scholar]
- 99.Gifford AL, Bormann JE, Shively MJ, Wright BC, Richman DD, Bozzette SA. Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug antiretroviral regimens. J Acquir Immune Defic Syndr 2000;23(5):386–95. [DOI] [PubMed] [Google Scholar]
- 100.Barclay TR, Hinkin CH, Castellon SA, Mason KI, Reinhard MJ, Marion SD, et al. Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive status. Health Psychol 2007;26(1):40–9. [DOI] [PMC free article] [PubMed] [Google Scholar]
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