Abstract
Objectives
Diet plays a significant role in the carcinogenesis. However, few studies had been conducted to evaluate the association of dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer among community-based Chinese women.
Methods
We performed a cross-sectional analysis of screening data in 2304 women in an ongoing cohort of 40,000 women in China. Multivariable logistic regressions were modeled to evaluate the relationship between dietary mineral intake and CIN + risk.
Results
After adjusting for multiple confounders, several dietary minerals intake were significantly associated with CIN2 + risk. Dietary calcium intake concentration was associated with the risk of CIN2 + (1st quartile versus 4th quartile: OR = 1.52, 95% CI: 1.01–2.32). The similar results were also observed for magnesium (OR = 1.80, 95% CI: 1.20–2.68), phosphorus (OR = 1.69, 95% CI: 1.12–2.55), zinc (OR = 1.55, 95% CI: 1.03–2.34) and potassium (OR = 1.92, 95% CI: 1.28–2.88). The association between dietary calcium intake and CIN1 risk (2nd quartile compared with 4th quartile: OR = 1.36, 95% CI: 1.03, 1.80), potassium (OR = 1.90, 95% CI: 1.27, 2.85). However, seldom statistical association was observed between other dietary mineral intake and CIN1 risk.
Conclusions
Dietary nutrients such as calcium, magnesium, phosphorus, zinc, and potassium were associated with risk of CIN2+, supporting the hypothesis that dietary mineral intake play a role in the development of higher grad CIN and cervical cancer.
Funding Sources
This study is supported by the Special Public Welfare Industry Research of National Health and Family Planning Commission of China (grant 201402010); This study is supported by the applied basic research project of Shanxi province (grant 201601D011086).
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