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Model of TβRIII-SS function. TβRIII-SS induces epithelial-to-mesenchymal transition. TβRIII-SS (EMT) then decreases migration and invasion, potentially through decreased adhesion. TβRIII-SS also increases gemcitabine resistance, decreases tumorigenicity but increases tumor growth rate, potentially through inhibiting canonical TGF-β signaling and promoting non-canonical TGF-β signaling.
