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. Author manuscript; available in PMC: 2019 Aug 28.
Published in final edited form as: Oncogene. 2019 Feb 28;38(25):4977–4989. doi: 10.1038/s41388-019-0768-8

Figure 1. c-Myc level and activity positively correlate with AR level in human prostate cancer samples.

Figure 1.

A-C, Pearson’s correlation coefficient analysis showing positive correlation between c-Myc and AR levels and between c-Myc activity score and AR level in 159 metastatic CRPC (mCRPC) samples (A), a meta dataset of 1642 primary prostate cancer (PC) samples (B), and the 500 TCGA primary prostate cancer samples (C). The c-Myc activity score was computed as the sum of z-scores for the Schuhmacher c-Myc-target signature. For analysis of correlation between expression levels and activity scores, the expression levels were computed as the z-scores for AR levels. D, GSEA showing enrichment of the hallmark Myc_targets_v1 pathway in mCRPC samples that express a high level of AR. TPM, transcripts per million.