Table 1.

Inhibition of biotinylated vitronectin binding to human integrin α_vβ₃. IC₅₀ values were determined as the compound concentration necessary for 50 % inhibition of biotinylated vitronectin binding as calculated using the software GraphPad Prism. All values are the average±standard deviation of duplicate measurements.

Cmpd	Structure	IC50 [nM] αvβ3
1	cyclo[DKP‐RGD]	4.5±1.1
3	cyclo[DKP‐isoDGR]	9.2±1.1
10	cyclo[DKP‐RGD]‐VA‐Cry‐55gly	7.2±1.5
11	cyclo[DKP‐isoDGR]‐VA‐Cry‐55gly	5.5±2.8
13	cyclo[DKP‐RGD]‐Cry‐55gly	24.1±1.0
14	cyclo[DKP‐isoDGR]‐Cry‐55gly	10.2±0.4