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. Author manuscript; available in PMC: 2019 Jun 21.
Published in final edited form as: Neuron. 2018 Feb 7;97(3):611–625.e5. doi: 10.1016/j.neuron.2018.01.037

Figure 7. Presynaptic inhibition of PKA eliminates ACh-enhancement of Pyr-SST synapses.

Figure 7.

(A) Schematic of the stimulation protocol. 1-single blue light (10 ms) was delivered 200 ms prior to the presynaptic spike train in the presence of PKA inhibitor peptide in the presynaptic Pyr cell. (B) The averaged trace of EPSP under baseline/light OFF and light ON conditions. Heatmaps at bottom show response amplitude for both conditions as described in previous figures. (C) Mean EPSP amplitude in response to the first spike in the train, for both conditions. (D) Mean failure rate after the first spike, for both conditions. For all, open circles represent individual cell measurements and filled circles represent all-cell mean± SEM, respectively (C,D). See also Figure S5.