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Comparison of mRNA folding with the 2 different rs2653349 alleles. Structures were generated using the mfold program. (A) The mRNA structure with the A allele has an initial folding energy of ΔG = −34.34 kcal/mol. (B) The mRNA structure with the G allele has a mean folding energy of ΔG = −36.70 kcal/mol. The G allele leads to a small additional loop in the mRNA structure.
