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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Prostate. 2019 Apr 18;79(9):980–993. doi: 10.1002/pros.23809

Figure 5. A Subset of Male NOD Mice Develop Areas of PIN-Like Changes.

Figure 5.

A) Areas of PIN-like changes in non-diabetic (ND) and diabetic (Di) mice. Arrows indicate enlarged nuclei or increased nuclear-cytoplasmic ratio. B) Representative H&E staining showing no breakdown of extracellular matrix in areas of PIN (arrowheads indicate intact basement membrane, arrow indicates inflammation) C) c-Myc staining revealed positive expression in regions with PIN-Like changes. D) MMP2 and MMP9 staining show increased expression in diabetic mice.