Table 1:

Timeline and study procedures.

Time	Week 1	Weeks 2-4	Weeks 5-6	Week 7	Weeks 8-10	Week 11
Procedures	Qualifying assessments	3 weeks at full drug dosing	Drug dosing lowered, then withdrawn		3 weeks at full drug dosing	Drug dosing lowered, then withdrawn
	Initial questionnaires		2 week drug washout period
	Pre-intervention nurse visit (#1/4)	Nurse visit in first week of full dosing, drug 1 (#2/4)			Nurse visit in first week of full dosing, drug 2 (#3/4)	Post-intervention nurse visit (#4/4)
	Baseline testing sessions 1, 2, & 3 for drug 1	Post-testing sessions 1 & 2 at 16 mg/kg dose		Baseline testing sessions 1, 2, & 3 for drug 2	Post-testing sessions 1 & 2 at 16 mg/kg dose
	Drug step-up	Post-testing session 3 at 32 mg/kg dose		Drug step-up, then full dosing drug 2	Post-testing session 3 at 32 mg/kg dose
Phase	Drug 1 at 16 mg/kg dose	Drug 1		Cross-over to drug 2 at 16 mg/kg dose	Drug 2
	(Placebo or octanoic acid)	(Placebo or octanoic acid)		(Placebo or octanoic acid)	(Placebo or octanoic acid)