1IRCCS Neuromed, 86077 Pozzilli, (IS) Italy
2Department of Medicine and Surgery, University of Salerno, Fisciano, 84084 (SA) Italy
3Cardiovascular Research Unit, IRCCS MultiMedica, 20099 Sesto San, Giovanni (MI) Italy
4Institute of Biomedical Technologies, National Research Council, 20090 Segrate, (MI) Italy
5University of Milan, Via Festa del Perdono, 20122 Milan, Italy
6Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126 Italy
7Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy
8Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri, 27100 Pavia, Italy
9Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy
10Diabetes Endocrine and Metabolic Diseases Unit, IRCCS MultiMedica, 20099 Sesto San, Giovanni (MI) Italy
11Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomedica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
12Department of Cardiovascular and Metabolic Diseases, IRCCS MultiMedica, 20099 Sesto San, Giovanni (MI) Italy
13TIGEM (Telethon Institute of Genetics and Medicine), 80078 Pozzuoli, Italy
14Department of Translational Medicine, “Federico II” University, Napoli, Italy
© The Author(s) 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.