Abstract
Few studies have examined the asthma burden among small racial/ethnic minority groups such as Asian children. We examined asthma disparities among children aged 4-17 in 6 small non-Hispanic racial/ethnic minority groups (American Indian/Alaska Native [AI/AN], Asian Indian, Chinese, Filipino, other Asian, and multiple race) by using the 2006-2015 National Health Interview Survey. These small minority groups represented a weighted 6.1% of the study population (6770 of 88 049). The prevalence of current asthma ranged from 5.5% (95% confidence interval [CI], 3.5%-7.5%) among Chinese children to 13.8% (95% CI, 10.4%-17.2%) among multiple-race children and 14.6% (95% CI, 10.8%-18.4%) among AI/AN children. Compared with non-Hispanic white children, AI/AN (adjusted odds ratio [aOR] = 1.6; 95% CI, 1.2-2.2) and multiple-race (aOR = 1.4; 95% CI, 1.0-2.0) children had higher odds for current asthma. Several small racial/ethnic minority groups are at heightened risk of asthma-associated outcomes, highlighting the need for further research on these populations.
Keywords: pediatrics, population surveillance, Asian American, American Indian, Native American
Studies of disparities in pediatric asthma in the United States have mainly focused on non-Hispanic black children,1-4 and little is known about the burden of asthma among other, smaller minority groups such as Asian children. This burden is not usually described in national studies because of small sample sizes.5 Only 1 study described the burden of asthma among smaller minority groups; it used data from the 2001-2005 National Health Interview Survey (NHIS) to show that asthma prevalence ranged from 4.4% among Asian Indian children to 13.0% among American Indian/Alaska Native (AI/AN) children.6 We used the most recent NHIS data (2006-2015), which began oversampling Asians in 2006,6,7 to update population estimates of asthma disparities among Asian and other non-Hispanic white, non-Hispanic black, and small non-Hispanic racial/ethnic minority groups.
Methods
The NHIS is a cross-sectional household interview survey of the civilian noninstitutionalized US population that is conducted by the National Center for Health Statistics using a complex, multistage sample design.7 The NHIS oversamples black and Hispanic persons and started oversampling Asians in 2006.6,7 To our knowledge, this study is the first to use updated NHIS data to study asthma burden primarily focusing on Asian subgroups.
Our analysis focused on children aged 4-17 (N = 88 049). We excluded children aged ≤3 because of uncertainties about asthma diagnosis in this age group.8,9 We focused on 3 asthma outcomes: current asthma, asthma attack/episode, and asthma emergency department (ED) visit.3,6,10,11 Survey questions about the child’s asthma outcomes were answered by a parent or adult who was knowledgeable about and responsible for the sample child. We defined those who answered “yes” to the screening question, “Has a doctor or other health professional ever told you that [child] had asthma?” and “yes” to the question, “Does [child] still have asthma?” as having current asthma. We defined children with current asthma who also answered “yes” to the question, “During the past 12 months, has [child] had an episode of asthma or an asthma attack?” as having had at least 1 asthma attack/episode. Subsequently, we defined only children who had current asthma and answered “yes” to the question, ”During the past 12 months, did [child] have to visit an emergency room or urgent care center because of his/her asthma?” as having at least 1 asthma ED visit.
We excluded from analysis children with missing responses (n = 97) or with answers such as “refused” (n = 83), “not ascertained” (n = 13), and “don’t know” (n = 7) for each asthma question. We also excluded 320 children whose primary race was not available in the public use data. The total study population (N = 88 049) was used as the denominator to define current asthma, and the count of children with current asthma (n = 9452) was used as the denominator to define asthma attack/episode and asthma ED visits when estimating the weighted prevalence of these 2 asthma outcomes.
We used 9 racial/ethnic groups according to Hispanic origin and race variables from NHIS: non-Hispanic white, non-Hispanic black, Hispanic, AI/AN, Asian Indian, Chinese, Filipino, other Asian, and multiple race.11 Other Asian included Korean, Vietnamese, Japanese, and other Asian subgroups. Multiple race refers to self-identifying with >1 race and no primary race selected. Although we focused on comparing the 6 small minority groups with non-Hispanic white children, we kept the results for non-Hispanic black and Hispanic children as a point of reference and for completeness of reporting. We considered the following covariates: age (4-8, 9-13, 14-17); sex (male, female); place of birth (US-born, non–US-born); region of residence (Northeast, Midwest, South, West); household highest education level (<high school, high school/general educational development, >high school); health insurance (insured, uninsured); having a usual place for health care (≥1, none)6; self-reported food, respiratory, or skin allergy (yes, no)2; and survey year to account for the secular trend.11 We used the ratio of family income to the applicable federal poverty level (FPL) thresholds from the imputed income data (imputation file 1) and categorized it as <100% FPL, 100%-249% FPL, and ≥250% FPL.12 None of the covariates had more than 1% missing values.
We conducted all analyses by using SAS version 9.413 survey procedures, and we applied sampling strata, cluster, and weights to account for the NHIS design.7,14 We summarized and compared population-weighted prevalence according to race/ethnicity by using the Rao-Scott χ2 test. We used survey logistic regression analysis to assess the association between dichotomized asthma outcomes and racial/ethnic groups after adjusting for the aforementioned covariates. We conducted sensitivity analyses on a subset of data excluding Hispanic children, and we tested for a nonlinear effect of time by including the quadratic term of the survey years. We considered P < .05 to be significant.
Results
Racial/ethnic groups other than non-Hispanic white (56.8%), non-Hispanic black (14.9%), or Hispanic (22.2%) children composed approximately 6.1% of the total weighted study population (Table 1). Among these 6 small minority groups, the prevalence of current asthma was highest among AI/AN children (14.6%; 95% confidence interval [CI], 10.8%-18.4%) and lowest among Chinese children (5.5%; 95% CI, 3.5%-7.5%). Among children with current asthma, the prevalence of asthma ED visits was highest among AI/AN children (26.5%; 95% CI, 11.0%-42.0%) and lowest among Asian Indian children (10.1%; 95% CI, 1.5%-18.8%). The prevalence of all asthma outcomes, except for asthma attack/episode, varied significantly across the 9 racial/ethnic groups (Table 1), with non-Hispanic black children having the highest prevalence of current asthma (16.4%; 95% CI, 15.7%-17.2%) and asthma ED visits (29.0%; 95% CI, 26.2%-31.7%), followed by AI/AN children. All covariates except for sex were significantly different across all 9 racial/ethnic groups.
Table 1.
Characteristics | Crude No. (N = 88 049) | Non- Hispanic White, % (n = 40 968) | Non- Hispanic Black, % (n = 14 668) | Hispanic, % (n = 25 643) | American Indian/ Alaska Native, % (n = 758) | Chinese, % (n = 1062) | Filipino, % (n = 1171) | Asian Indian, % (n = 1102) | Other Asian,b % (n = 1929) | Multiple Races,c % (n = 748) | P Valued |
---|---|---|---|---|---|---|---|---|---|---|---|
Total | 88 049 | 56.8 | 14.9 | 22.2 | 0.9 | 0.8 | 1.0 | 1.0 | 1.7 | 0.7 | |
US-borne | <.001 | ||||||||||
Yes | 88 000 | 98.3 | 96.7 | 88.5 | 99.7 | 73.4 | 79.7 | 75.5 | 75.6 | 98.0 | |
No | |||||||||||
Sex | .57 | ||||||||||
Male | 45 410 | 51.2 | 50.8 | 51.0 | 51.9 | 47.3 | 50.4 | 49.7 | 51.5 | 47.2 | |
Female | |||||||||||
Age group, y | <.001 | ||||||||||
4-8 | 29 654 | 34.4 | 35.2 | 38.8 | 32.1 | 37.0 | 31.8 | 46.0 | 35.7 | 42.6 | |
9-13 | 30 087 | 35.8 | 35.7 | 34.6 | 40.4 | 34.1 | 38.9 | 32.9 | 37.1 | 34.5 | |
14-17 | 28 308 | 29.8 | 29.2 | 26.6 | 27.5 | 28.9 | 29.4 | 21.1 | 27.1 | 22.8 | |
Geographic region | <.001 | ||||||||||
Northeast | 14 212 | 18.1 | 16.1 | 12.7 | 3.9 | 25.1 | 15.0 | 26.0 | 16.8 | 14.3 | |
Midwest | 17 629 | 30.0 | 20.4 | 10.1 | 18.9 | 15.3 | 10.4 | 20.7 | 17.9 | 27.2 | |
South | 31 976 | 33.7 | 55.4 | 35.3 | 30.1 | 18.3 | 19.8 | 29.4 | 25.0 | 23.1 | |
West | 24 232 | 18.2 | 8.1 | 41.9 | 47.1 | 41.3 | 54.7 | 23.9 | 40.3 | 35.4 | |
Poverty status | <.001 | ||||||||||
<100% FPL | 17 774 | 11.1 | 35.4 | 33.4 | 35.6 | 11.8 | 7.1 | 10.2 | 17.9 | 14.8 | |
100%-249% FPL | 29 025 | 27.4 | 36.2 | 42.1 | 36.6 | 21.2 | 28.8 | 18.4 | 34.7 | 30.9 | |
≥250% FPL | 41 250 | 61.4 | 28.4 | 24.5 | 27.9 | 67.1 | 64.0 | 71.4 | 47.4 | 54.3 | |
Highest education level in household | <.001 | ||||||||||
<High school | 10 137 | 3.6 | 11.6 | 28.2 | 6.7 | 4.9 | 1.4 | 2.3 | 9.0 | 3.7 | |
High school/general educational development | 18 398 | 16.9 | 25.4 | 25.9 | 29.6 | 12.4 | 10.0 | 6.5 | 16.8 | 14.4 | |
>High school | 59 278 | 79.4 | 63.0 | 45.9 | 63.7 | 82.6 | 88.6 | 91.2 | 74.3 | 81.8 | |
No health insurancee | 7786 | 5.7 | 5.8 | 14.7 | 17.3 | 6.4 | 6.2 | 5.8 | 9.2 | 4.6 | <.001 |
No usual place for health caree | 4792 | 3.4 | 4.2 | 8.5 | 5.5 | 5.5 | 6.1 | 4.1 | 7.4 | 4.5 | <.001 |
Respiratory allergye | 10 496 | 13.3 | 11.4 | 9.1 | 13.4 | 9.3 | 10.5 | 9.1 | 7.8 | 17.0 | <.001 |
Food/digestive allergye | 4500 | 5.1 | 5.4 | 4.0 | 7.2 | 5.4 | 6.4 | 5.9 | 5.1 | 7.9 | <.001 |
Eczema/skin allergye | 9736 | 10.8 | 14.9 | 9.1 | 10.1 | 11.4 | 12.5 | 10.0 | 10.8 | 16.8 | <.001 |
Current asthma | 9452 | 9.2 | 16.4 | 9.5 | 14.6 | 5.5 | 10.1 | 6.0 | 6.0 | 13.8 | <.001 |
≥1 Asthma attack/episode in past 12 monthsf | 4898 | 54.9 | 51.3 | 50.9 | 49.6g | 67.0h | 52.6 | 59.8 | 49.1 | 62.2 | .17 |
≥1 Asthma ED visit in past 12 monthsf | 1573 | 14.5 | 29.0 | 23.1 | 26.5 | 15.0 | 12.9 | 10.1 | 20.3 | 22.8 | <.001 |
Abbreviations: ED, emergency department; FPL, federal poverty level.
aData source: Centers for Disease Control and Prevention.7 The standard error (SE) of weighted prevalence ranged from 0.4% to 9.4%.
bOther Asian includes Korean, Vietnamese, Japanese, and other Asian subgroups.
cMultiple race indicates self-identifying with >1 race and not selecting a primary race.
dRao-Scott χ2 test to compare the weighted prevalence of characteristics by race/ethnicity. P < .05 indicates significant associations between race/ethnicity and the corresponding covariate.
eThe proportions of missing data for the following variables were: nativity, 0.06%; education, 0.03%; health insurance status, 0.04%; usual place for care, 0.02%; respiratory allergy, 0.02%; food/digestive allergy, 0.01%; eczema/skin allergy, 0.01%.
fAmong children with current asthma. Weighted prevalence that took into account the survey design was summarized according to racial/ethnic groups and compared by using the Rao-Scott χ2 test. Percentages may not total to 100.0 because of rounding.
gFor American Indian/Alaska Native children, the SE was >9%.
hFor Chinese children, the SE was >8% but <9%.
Compared with non-Hispanic white children, non-Hispanic black, Hispanic, AI/AN, and multiple-race children had significantly higher odds of current asthma (Table 2). Compared with non-Hispanic white children, other Asian children had lower odds of current asthma (adjusted odds ratio [aOR] = 0.8; 95% CI, 0.6-1.0), and both non-Hispanic black (aOR = 2.3; 95% CI, 1.9-2.8) and Hispanic (aOR = 1.7; 95% CI, 1.4-2.1) children had higher odds of asthma ED visits. These results did not change in the sensitivity analysis among non-Hispanic children and when the quadratic term of survey year was used.
Table 2.
Variable | Current Asthma | ≥1 Asthma Attack/Episode in Past 12 Months | ≥1 Asthma ED Visit in Past 12 Months | |||
---|---|---|---|---|---|---|
Weighted Prevalence (95% CI) | aOR (95% CI) | Weighted Prevalence (95%CI) | aOR (95% CI) | Weighted Prevalence (95% CI) | aOR (95% CI) | |
Race/ethnicity | ||||||
Non-Hispanic white | 9.2 (8.8-9.7) | 1.0 [Reference] | 54.9 (52.8-57.1) | 1.0 [Reference] | 14.5 (13.0-16.1) | 1.0 [Reference] |
Non-Hispanic black | 16.4 (15.7-17.2) | 1.9 (1.8-2.1) | 51.3 (48.8-53.8) | 0.9 (0.8-1.0) | 29.0 (26.2-31.7) | 2.3 (1.9-2.8) |
Hispanic | 9.5 (9.0-9.9) | 1.2 (1.1-1.3) | 50.9 (48.4-53.4) | 0.8 (0.7-0.9) | 23.1 (20.7-25.5) | 1.7 (1.4-2.1) |
American Indian/Alaska Native | 14.6 (10.8-18.4) | 1.6 (1.2-2.2) | 49.6 (31.2-68.0)c | 0.8 (0.4-1.6) | 26.5 (11.0-42.0) | 2.2 (0.9-5.4) |
Chinese | 5.5 (3.5-7.5) | 0.7 (0.5-1.1) | 67.0 (49.9-84.2)d | 1.4 (0.7-3.1) | 15.0 (0.0-30.7) | 0.9 (0.3-3.3) |
Filipino | 10.1 (7.5-12.6) | 1.3 (1.0-1.8) | 52.6 (38.4-66.9) | 0.8 (0.5-1.5) | 12.9 (5.7-20.2) | 0.9 (0.4-1.9) |
Asian Indian | 6.0 (4.0-8.0) | 0.8 (0.6-1.1) | 59.8 (45.6-74.0) | 1.1 (0.6-2.1) | 10.1 (1.5-18.8) | 0.8 (0.3-2.1) |
Other Asiane | 6.0 (4.7-7.3) | 0.8 (0.6-1.0) | 49.1 (38.5-59.7) | 0.8 (0.5-1.4) | 20.3 (11.1-29.6) | 1.8 (1.0-3.5) |
Multiple racef | 13.8 (10.4-17.2) | 1.4 (1.0-2.0) | 62.2 (50.8-73.6) | 1.3 (0.8-2.2) | 22.8 (8.3-37.2) | 1.6 (0.6-4.0) |
US-born | ||||||
No | 4.8 (4.0-5.5) | 1.0 [Reference] | 52.5 (44.7-60.4) | 1.0 [Reference] | 19.8 (12.7-26.8) | 1.0 [Reference] |
Yes | 10.6 (10.3-10.9) | 2.0 (1.6-2.3) | 53.3 (51.8-54.7) | 0.9 (0.6-1.2) | 20.0 (18.7-21.2) | 0.9 (0.5-1.5) |
Sex | ||||||
Female | 8.9 (8.5-9.3) | 1.0 [Reference] | 53.1 (50.9-55.3) | 1.0 [Reference] | 18.2 (16.4-20.0) | 1.0 [Reference] |
Male | 11.7 (11.3-12.1) | 1.3 (1.2-1.4) | 53.3 (51.4-55.3) | 1.0 (0.9-1.1) | 21.2 (19.7-22.7) | 1.2 (1.0-1.3) |
Age group, y | ||||||
4-8 | 9.8 (9.4-10.3) | 1.0 [Reference] | 60.4 (58.1-62.6) | 1.0 [Reference] | 28.5 (26.3-30.8) | 1.0 [Reference] |
9-13 | 10.8 (10.3-11.2) | 1.1 (1.1-1.2) | 51.9 (49.5-54.3) | 0.7 (0.6-0.8) | 16.8 (15.1-18.5) | 0.5 (0.5-0.6) |
14-17 | 10.4 (9.9-10.9) | 1.2 (1.1-1.3) | 46.6 (44.2-49.0) | 0.6 (0.5-0.7) | 13.4 (11.4-15.5) | 0.4 (0.4-0.5) |
Geographic region | ||||||
West | 8.9 (8.5-9.4) | 1.0 [Reference] | 55.0 (51.8-58.1) | 1.0 [Reference] | 17.6 (15.4-19.7) | 1.0 [Reference] |
Northeast | 11.7 (11.0-12.5) | 1.3 (1.2-1.4) | 50.4 (46.9-53.8) | 0.8 (0.7-1.0) | 20.4 (17.6-23.3) | 1.2 (0.9-1.5) |
Midwest | 10.3 (9.6-11.0) | 1.1 (1.0-1.2) | 51.8 (48.7-55.0) | 0.8 (0.7-1.0) | 19.3 (16.4-22.3) | 1.1 (0.9-1.5) |
South | 10.6 (10.2-11.1) | 1.0 (0.9-1.1) | 54.6 (52.3-57.0) | 0.9 (0.8-1.1) | 21.4 (19.4-23.3) | 1.1 (0.9-1.3) |
Poverty status | ||||||
≥250% FPL | 9.0 (8.7-9.4) | 1.0 [Reference] | 52.8 (50.6-55.1) | 1.0 [Reference] | 15.2 (13.5-16.9) | 1.0 [Reference] |
100%-249% FPL | 10.3 (9.8-10.8) | 1.2 (1.1-1.3) | 53.0 (50.5-55.4) | 1.1 (1.0-1.3) | 22.0 (19.8-24.3) | 1.4 (1.1-1.8) |
<100% FPL | 13.5 (12.8-14.1) | 1.6 (1.4-1.7) |
54.2 (51.5-57.0) | 1.3 (1.1-1.5) |
24.8 (22.4-27.3) | 1.5 (1.2-1.9) |
Highest level of education in household | ||||||
>High school | 10.2 (9.8-10.5) | 1.0 [Reference] | 55.3 (53.5-57.0) | 1.0 [Reference] | 18.8 (17.4-20.3) | 1.0 [Reference] |
High school/general educational development | 11.1 (10.5-11.8) | 1.1 (1.0-1.2) | 48.5 (45.5-51.5) | 0.8 (0.7-0.9) | 21.9 (19.4-24.4) | 1.0 (0.9-1.2) |
<High school | 10.0 (9.2-10.8) | 1.0 (0.9-1.1) | 49.8 (45.2-54.4) | 0.8 (0.6-1.0) | 23.4 (19.7-27.0) | 1.0 (0.8-1.3) |
Health insurance | ||||||
Yes | 10.6 (10.3-10.9) | 1.0 [Reference] | 53.2 (51.7-54.7) | 1.0 [Reference] | 19.8 (18.6-21.1) | 1.0 [Reference] |
No | 7.2 (6.4-8.0) | 0.8 (0.7-0.9) | 54.4 (48.8-60.0) | 1.1 (0.9-1.5) | 21.7 (16.9-26.6) | 1.1 (0.8-1.5) |
Usual place for health care | ||||||
No | 5.3 (4.4-6.2) | 1.0 [Reference] | 45.3 (37.2-53.5) | 1.0 [Reference] | 14.6 (8.0-21.2) | 1.0 [Reference] |
Yes | 10.6 (10.3-10.9) | 1.7 (1.4-2.0) | 53.5 (52.0-54.9) | 1.3 (1.0-1.8) | 20.1 (18.9-21.3) | 1.5 (0.8-2.7) |
Respiratory allergy | ||||||
No | 7.2 (7.0-7.5) | 1.0 [Reference] | 46.3 (44.4-48.1) | 1.0 [Reference] | 16.8 (15.3-18.3) | 1.0 [Reference] |
Yes | 32.8 (31.6-34.0) | 5.6 (5.2-6.0) | 64.2 (62.1-66.4) | 1.9 (1.7-2.1) | 24.4 (22.4-26.4) | 1.7 (1.5-2.0) |
Food/digestive allergy | ||||||
No | 9.5 (9.2-9.8) | 1.0 [Reference] | 51.6 (50.0-53.2) | 1.00 [Reference] | 19.3 (18.0-20.5) | 1.0 [Reference] |
Yes | 26.0 (24.2-27.8) | 2.0 (1.8-2.3) | 64.4 (60.6-68.3) | 1.4 (1.1-1.7) | 24.3 (20.3-28.3) | 1.2 (0.9-1.5) |
Eczema/skin allergy | ||||||
No | 9.0 (8.7-9.2) | 1.0 [Reference] | 50.6 (48.9-52.2) | 1.00 [Reference] | 18.6 (17.2-20.0) | 1.00 [Reference] |
Yes | 21.3 (20.2-22.4) | 1.8 (1.7-2.0) | 62.2 (59.6-64.9) | 1.3 (1.1-1.5) | 24.2 (21.9-26.5) | 1.1 (0.9-1.3) |
Survey year (2006-2015) | 1.0 (1.0-1.0) | 1.0 (1.0-1.0) | 0.9 (0.9-0.9) |
Abbreviations: aOR, adjusted odds ratio; ED, emergency department; FPL, federal poverty level.
aSurvey logistic regression analysis was used to assess the association between dichotomized asthma outcomes and race/ethnicity after adjusting for all listed covariates. The listwise deletion method was used to handle missing data in the model. The total sample sizes were 86 942 for current asthma, 9314 for asthma attack/episode, and 7835 for asthma ED visits in models. The percentages of missing values were 1.3% for current asthma, 1.8% for asthma attack/episode, and 2.0% for asthma ED visits. The denominator used to define asthma attack/episode and asthma ED visit was children with current asthma.
bData source: Centers for Disease Control and Prevention.7
cFor American Indian/Alaska Native children, the standard error (SE) was >9%.
dFor Chinese children, the SE was >8% but <9%.
eOther Asian includes Korean, Vietnamese, Japanese, and other Asian subgroups.
fMultiple race indicates self-identifying with >1 race and not selecting a primary race.
Discussion
Our study augments a previous study6 by confirming a heterogeneous pattern of asthma prevalence among small racial/ethnic minority groups. Compared with non-Hispanic white children, AI/AN and multiple-race children had higher odds of current asthma. Although most pediatric asthma research has focused on non-Hispanic black children because of the high prevalence of asthma in that group, our study showed that multiple-race, AI/AN, and Filipino children also bore a disproportionately high asthma burden, similar to that seen among non-Hispanic black children. Our results are consistent with the results of a study on pediatric asthma that was based on NHIS data from 2008-2010 that found the highest prevalence of asthma among the multiple-race group, followed by non-Hispanic black and AI/AN children; however, that study did not differentiate among Asian subgroups.15
Data on small minority groups such as AI/ANs or Asian subgroups have not typically been reported in studies of national asthma trends.5,6,16 Because of the oversampling of Asian groups in NHIS since 2006 and because we used 10 years of these data, our study may improve the precision of estimates of small minority groups, particularly Asian subgroups. However, our study had several limitations. First, we did not adjust for family history of asthma, environmental smoke exposure, and other potential confounders. Second, data on asthma outcomes and allergy status were based on self-reported answers that were not validated against clinically defined outcomes; as such, they may be subject to information and recall bias. Third, although we adjusted for sample year in the main model and tested quadratic terms of the sample year in the sensitivity analysis, other nonlinear time trends may exist. Finally, although we compared the prevalence of asthma among groups defined by race/ethnicity, the results may not be directly comparable with results of studies that use race alone to define subgroups.3,6,15
We found that some racial/ethnic minority groups, such as AI/AN, Filipino, and multiple races, had a prevalence of asthma that was higher than the reported national level, which ranged from 7.3% in 2001 to 8.4% in 2010.15 Other studies also found a higher burden of asthma among AI/AN and/or Filipino children, with multiple underlying socioeconomic and health access factors, such as high hospitalization costs, inadequate asthma knowledge, and poor asthma management.17-23 Our study suggests the need for further studies of these small minority groups to understand and intervene on asthma outcomes in diverse racial/ethnic groups.
Footnotes
Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Funding: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The work of Dr. Sheffield was supported by the National Institutes of Health grants K23ES024127.
ORCID iD: Chi Wen, BSc https://orcid.org/0000-0002-2428-7363
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