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. 2017 Jan 24;32(1):23–31. doi: 10.1007/s12250-016-3902-6

Recent advances in the identification of the host factors involved in dengue virus replication

Yi Wang 1,2, Ping Zhang 1,2,✉
PMCID: PMC6598876  PMID: 28124222

Abstract

Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection. graphic file with name 12250_2016_3902_Fig1_HTML.jpg

Keywords: dengue virus (DENV), host factors, replication, proteins, miRNAs

Acknowledgments

This work was supported by the National Natural Science Foundation of China (81371794) and Guangdong Natural Science Foundation (2014A030311007).

Footnotes

ORCID: 0000-0002-5400-8767

Compliance with Ethics Guidelines

The authors declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors.

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