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. 2017 Aug 18;32(6):533–536. doi: 10.1007/s12250-017-4000-0

Interplay between hepatitis C virus and ARF4

Na Zhang 1, Youyang Ke 2,✉, Leiliang Zhang 1,✉
PMCID: PMC6598887  PMID: 28840565

Abstract

In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.

graphic file with name 12250_2017_4000_Fig1_HTML.jpg

Contributor Information

Youyang Ke, Email: keyouyang001@163.com.

Leiliang Zhang, Email: armzhang@hotmail.com.

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Articles from Virologica Sinica are provided here courtesy of Wuhan Institute of Virology, Chinese Academy of Sciences

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