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. 2019 Jun 9;9(15):4391–4408. doi: 10.7150/thno.32462

Figure 6.

Figure 6

ZnAs@SiO2 NPs inhibit stemness and EMT via SHP-1/JAK2/STAT3 signaling pathway. (A) Protein levels of SHP-1, p-JAK2, JAK2, p-STAT3 and STAT3 in MHCC97L and Hep3b cells after treatment with PBS, ATO or ZnAs@SiO2 NPs for 24 h. (B) ZnAs@SiO2 NPs inhibit JAK2/STAT3 mediated by SHP-1. (C) ZnAs@SiO2 NPs inhibit stemness and EMT mediated by SHP-1. (D-I) Colony formation assay (D), Sphere formation assay (E), Transwell migration assay (G) and invasion assay (H) of MHCC97L and Hep3b cells after treatment with ZnAs@SiO2 NPs with or without si-SHP-1 and quantification (F, I), Scale bar, 50 µm. (J) Data from TCGA public database showing the negative correlation between mRNA levels of SHP-1 and tumor TNM staging and Child-Pugh grading. *, P < 0.05; **, P < 0.01; ***, P < 0.001.