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Residues K5.70 and T7.54 identified by the D2R sensitivity analysis determine the helicity of the intracellular TM5 extension. (A) The distance between the backbone oxygen of K5.70 and the backbone amide hydrogen of T5.74 along trajectories of D2R bound to the full agonist (in blue) and the inverse agonist (red). (B) Illustrative frames from the trajectories in panel A chosen for the distinct difference in the distance, and its effect on the helicity of the intracellular end of TM5.
