Scheme 2.
Synthesis of DX-02-07. (a) P2S5, NaHCO3, dry tetrahydrofuran, yield = 75%; (b) CH3I, K2CO3, acetone, yield = 83%; (c) 1H-pyrrole-2,5-dione, CH3CO2H, yield = 61%; (d) m-CPBA, dry dichloromethane, yield = 35%.
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