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. Author manuscript; available in PMC: 2020 Jul 1.
Published before final editing as: Reproduction. 2019 Jan 1:REP-18-0239.R2. doi: 10.1530/REP-18-0239

Figure 3: Schematic representation of the NOTCH signaling pathway.

Figure 3:

Ligands of the JAGGED (JAG) and DELTA-like families interact with NOTCH1–4 receptors on an adjacent cell. In the seminiferous epithelium, JAG1 at the surface of spermatogonia interacts with NOTCH1 at the surface of Sertoli cells. This releases the NOTCH intracellular domain (NICD), which translocates to the Sertoli cell nucleus. NICD forms a complex with RBPJ at the promoter of target genes. Binding of NICD releases co-repressors and allows the binding of co-activators. This leads to the transcriptional activation of the canonical NOTCH targets Hes1 and Hey1, which are known bHLH transcriptional repressors.