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. 2019 May 10;44:361–374. doi: 10.1016/j.ebiom.2019.05.008

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — LTA4H mediates cell transformation. (a) Knockdown of LTA4H expression in DLD-1 and HCT-15 colon cancer cell lines. (b) LTB4 production is decreased in DLD-1 and HCT-15 colon cancer cell lines after knockdown of LTA4H. The data are shown as mean values ± S.E. from triplicate experiments. The asterisk (*) indicates a significant (p < .05) decrease in LTB4 production in shLTA4H cells compared to shMOCK cells. (c) DLD-1 or HCT-15 cells were transfected with shLTA4H or shMOCK and grown in soft agar and then colonies were counted. The data are shown as mean values ± S.E. from triplicate experiments. The asterisk (*) indicates a significant (p < .05) decrease in colony formation in shLTA4H cells compared to shMOCK cells. (d) DLD-1 or HCT-15 colon cancer cells were transfected with shLTA4H or shMOCK. Cells were harvested and the expression levels of phosphorylated and total proteins were analyzed by Western blotting.