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PGT145 neutralizes HIV-1 and SHIV but not SIV. The indicated viruses were incubated with serial dilutions of PGT145 for 1 h at 37°C before addition to TZM-bl cells (A) or C8166-SEAP cells (B). After 3 days, neutralization was measured as a decrease in luciferase (A) or secreted alkaline phosphatase (SEAP) (B) activity (RLU) compared to mock-infected or virus-infected control wells without antibody. The dotted line indicates 50% neutralization.
