Fig. 6.

Chronic antibiotic administration increases the macromolecular permeability of rat distal ileum.

Group data for FITC flux in distal ileum (a, b) and proximal colon (c, d) in VEH and ABX (a, c) and in VEH-FMT and ABX-FMT rats (b, d). VEH, autoclaved deionised water; ABX, antibiotic-treated; VEH-FMT, VEH followed by faecal microbiota transfer; ABX-FMT, antibiotic-treated followed by faecal microbiota transfer. Groups (a-d) showing baseline (0 min), 60 min and 120 min FITC flux for VEH (n = 4–5), ABX (n = 6), VEH-FMT (n = 5) and ABX-FMT (n = 4). Groups were statistically compared by two-way ANOVA with Bonferroni post hoc, where appropriate. * p < .05, ABX versus VEH.