Filamentous fungi are important etiological agents of keratitis globally. Hyaline hyphomycetes including Fusarium and Aspergillus spp. are most common, but dematiaceous fungi such as Curvularia and Bipolaris spp. though less common constitute approximately 20% of cases.[1] Commonly reported signs of fungal keratitis include feathery edges, raised lesions, hypopyon, stromal infiltrates, and less frequently, satellite lesions and ring infiltrates.[1] Lesions with macroscopic pigmentation presented with pigmented plaque like raised infiltrates are more commonly seen in dematiaceous keratitis compared to those seen in fungal keratitis of hyaline origin.[1] There occurs surface colonization of pigmented fungal filaments associated with mild-to-moderate inflammation and tissue destruction of the underlying corneal stroma. Aspergillus spp. is more likely to have a ring infiltrate, and Fusarium spp. are less likely to have a raised lesion or an endothelial plaque.[1]
Commonest isolate from dematiaceous fungal keratitis being Curvularia, reported from previous and current study.[2,3] Alternaria, Scedosporium, and Ulocladium being other less common causative agents. Trauma with vegetative matter has been reported as the commonest cause for this keratitis. Curvularia keratitis has been clustered and reported under warm and humid climatic conditions,[4] whereas this study has correlated it with harvest season in autumn and winter.[3] Diagnosis of this keratitis is not challenging and septate hyphae are commonly seen on scraping. When presenting early, response to topical natamycin is good, as minimal inhibitory concentration (MIC) of natamycin for curvularia keratitis is not high.[5] Management of Ulocladium and Scedosporium keratitis being challenging might need penetrating keratoplasty or evisceration in severe cases.
Comparative analysis of diagnosis and management of dematiaceous keratitis and hyaline keratitis in future may give better idea of prognosis and outcomes.
References
- 1.Oldenburg CE, Prajna VN, Prajna L, Krishnan T, Mascarenhas J, Vaitilingam CM, et al. Clinical signs in dematiaceous and hyaline fungal keratitis. Br J Ophthalmol. 2011;95:750–1. doi: 10.1136/bjo.2010.198648. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Garg P, Gopinathan U, Choudhary K, Rao GN. Keratomycosis: Clinical and microbiologic experience with dematiaceous fungi. Ophthalmology. 2000;107:574–80. doi: 10.1016/s0161-6420(99)00079-2. [DOI] [PubMed] [Google Scholar]
- 3.Kumar A, Khurana A, Sharma M, Chauhan L. Causative fungi and treatment outcome of dematiaceous fungal keratitis in North India. Indian J Ophthalmol. 2019;67:1048–53. doi: 10.4103/ijo.IJO_1612_18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Wilhelmus KR. Climatology of dematiaceous fungal keratitis. Am J Ophthalmol. 2005;140:1156–7. doi: 10.1016/j.ajo.2005.07.032. [DOI] [PubMed] [Google Scholar]
- 5.Pradhan L, Sharma S, Nalamada S, Sahu SK, Das S, Garg P. Natamycin in the treatment of keratomycosis: Correlation of treatment outcome and in vitro susceptibility of fungal isolates. Indian J Ophthalmol. 2011;59:512–4. doi: 10.4103/0301-4738.86328. [DOI] [PMC free article] [PubMed] [Google Scholar]