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. 2019 Jul 6;7:102. doi: 10.1186/s40168-019-0717-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Potential metabolic functional profiles differ by sample type but not health status. a SEED metabolic functional category profiles separate plaque and historic calculus in a principal component analysis. b SEED profiles of plaque and historic calculus are sufficiently discriminatory to cluster samples by type in the sparse partial least squares-discriminant analysis (sPLS-DA). c Healthy and periodontal disease site historic calculus SEED profiles overlap and are not distinctly separated by PCA. d Historic healthy and disease site calculus SEED profiles overlap and are not sufficiently discriminatory for distinct clustering by sPLS-DA