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. 2019 May 15;14(8):791–803. doi: 10.1080/15592294.2019.1615354

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Figure 4. — MYC combined with HDAC7 at OCT2 promoter to regulate the OCT2 expression in RCC cell line 786-O. (a) RT-qPCR analysis of HDAC7, HDAC9 and MYC mRNA expression in 786-O after treated with 2 µM SAHA for 48 h; (b, c) RT-qPCR analysis of MYC (b) and OCT2 (c) mRNA expression in 786-O cells after knockdown MYC and treated with 2µM SAHA for 48 h; (d) MYC and OCT2 protein expression in 786-O cells after knockdown MYC and treated with 2 µM SAHA for 48 h. (e) Co-IP analysis of HDAC7-MYC complex in 786-O cells after knockdown MYC and treated with 2µM SAHA for 48 h; (f) ChIP-qPCR analysis of HDAC7 enrichment at OCT2 promoter in 786-O cells after treated with 2 µM SAHA for 48 h; (G) ChIP-qPCR analysis of H3K18ac and H3K27ac enrichment at OCT2 promoter in 786-O cells after HDAC7 knockdown. The results are expressed as means ± S.D. from technical triplicates in a, b, c, f, g [a: one-tailed unpaired t-test: P = 0.0008].