Table 1.
Terms | Definitions |
---|---|
Clinical success- Clinical Cure |
Elimination of the signs & symptoms related to the initial infection for which minocycline or non-minocycline based therapies are used. |
Microbiological success- Microbiological Cure |
Eradication of the causative organism from the site of infection. |
Adverse Events | Onset of signs, symptoms or laboratory findings related to minocycline, its combinations or non-minocycline based regimens. |
Hospital-Acquired Infection | The date of the site-specific infection occurs on or after the 3rd calendar day of admission (the day of admission is calendar day 1) [29]. |
Antimicrobial resistance classification | MDR: non-susceptible to ≥ 1 agent of ≥ 3 classes of antibiotics, XDR: non-susceptible to ≥ 1 agent in all but ≤2 categories, and PDR: non-susceptible to all classes or agents [30]. |
Site of infection | Site of isolation of the MDR, XDR or PDR A. baumannii (or A. calcoaceticus-baumannii complex) strain in the context of a new onset of relevant signs, symptoms and laboratory markers attributable to infection, based on the treating clinicians’ decision. |
Surgical Site Infections | Infections that occur 30 days after surgery with no implant or within 1 year if an implant is placed and the infection appears to be related to surgery |
MDR: multidrug resistant, XDR: extensively drug resistant, PDR: pandrug resistant.