Table 4.

Summary of the Classic HLA Alleles and AA Polymorphisms Associated With Anti‐sp100

Variants	Position (hg19)	A1/A2	Reference of A1		P	OR (95% CI)	Region
			Anti‐sp100+	Anti‐sp100−
SNP
rs1794280	32667171	T/A	0.140	0.051	5.98 × 10−10	3.00 (2.09‐4.31)	Between DQB1 and DQA2
6‐32723737	32723737	−CC/A	0.111	0.036	1.26 × 10−9	3.37 (2.23‐5.09)	DQB2
rs113547322	32206619	T/G	0.313	0.177	1.36 × 10−9	2.12 (1.66–2.72)	Close to NOTCH4
rs9269173	32447188	A/T	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	Between DRA and DRB5
rs77689370	32549563	A/G	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
rs9269941	32551939	T/G	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
rs67476479	32551948	P/A	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
HLA alleles
HLA_DRB1_03	32552064	P/A	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
HLA_DRB1_0301	32552064	P/A	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
HLA_DQA1_0102	32608306	P/A	0.313	0.182	8.10 × 10−9	2.04 (1.60–2.61)	DQA1 noncoding
HLA_DQB1_0201	32631061	P/A	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DQB1 noncoding
HLA_DPB1_03	33049368	P/A	0.100	0.039	1.32 × 10−6	2.70 (1.78‐4.09)	DPB1 noncoding
HLA_DPB1_0301	33049368	P/A	0.100	0.039	1.32 × 10−6	2.70 (1.78‐4.09)	DPB1 noncoding
AA polymorphisms
AA_DRβ1_77_32551939	32551939	N/T	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
AA_DRβ1_74_32551948_R	32551948	P/A	0.135	0.050	1.51 × 10−9	2.97 (2.06‐4.29)	DRB1 coding
AA_DQα1_207_32610462_M	32610462	P/A	0.313	0.182	8.10 × 10−9	2.04 (1.60–2.61)	DQA1 coding
AA_DQα1_207_32610462_V	32610462	A/P	0.313	0.182	8.10 × 10−9	2.04 (1.60–2.61)	DQA1 coding
AA_DRβ1_71_32551957_K	32551957	P/A	0.135	0.054	1.87 × 10−8	2.73 (1.90‐3.92)	DRB1 coding
AA_DRβ1_70_32551960_Q	32551960	P/A	0.410	0.276	1.75 × 10−7	1.82 (1.45–2.28)	DRB1 coding

Abbreviations: A1, effective allele; A2, alternative allele; A, absent; P, present.