Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 12;11(6):1316. doi: 10.3390/nu11061316

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Aronia consumption downregulates mRNA expression of pro-inflammatory cytokines and up-regulates anti-inflammatory cytokines. Splenic CD4⁺CD62L⁺ cells from C57BL/6J mice were transferred to Rag1^-/- mice. Mice consumed the AIN-93M diet (colitic control) or aronia-supplemented diet for five weeks. A third group of Rag1^-/- mice received splenic CD4⁺ cells, consumed AIN-93M diet and served as the non-colitic control. The mRNA expressions of transcription factors of Foxp3 (forkhead box P3) and Rorc (RAR-related orphan receptor gamma), and cytokines of Il17a (interleukin 17A), Il22 (interleukin 22), Il6 (interleukin 6), Il10 (interleukin 10), Ifng (interferon-gamma), and Tnf (tumor necrosis factors) in the (A) colon (n = 4–5/group), (B) mesenteric lymph node (MLN) (n = 8–10/group), and (C) spleen (n = 3–5/group). The mRNA expressions were normalized to Eef2 (eukaryotic translation elongation factor 2) and Rplp0 (ribosomal protein large P0) genes. Data are means ± SEMs.