Table 5.
Association between levels of global DNA methylation with dietary intake of folate, alcohol, and methionine of patients undergoing pre-treatment for colorectal adenocarcinoma.
| Dietary Variables (Folate, Alcohol, and Methionine) |
Global DNA Methylation in Tumor (%) |
Global DNA Methylation in Blood (%) |
||||
|---|---|---|---|---|---|---|
| n | Mean (SD) | p | n | Mean (SD) | p | |
| Supplementation | 111 | 123 | ||||
| No | 99 | 52.02 (±24.60) | 0.85 | 111 | 27.13 (±19.89) | 0.81 |
| Yes | 12 | 50.68 (±21.65) | 12 | 26.47 (±6.97) | ||
| DFE diet 1 | 111 | 123 | ||||
| 1st tertile | 35 | 49.82 (±22.36) | 0.26 | 44 | 32.29 (±28.96) | 0.06 |
| 2nd tertile | 40 | 56.83 (±26.41) | 40 | 24.86 (±9.08) | ||
| 3rd tertile | 36 | 48.36 (±23.11) | 39 | 23.42 (±8.68) | ||
| DFE total 2 | 12 | 12 | ||||
| 1st tertile | 1 | 34.22 | 0.71 | 1 | 25.44 | 0.34 |
| 2nd tertile | 5 | 49.44 (±13.25) | 5 | 30.03 (±7.54) | ||
| 3rd tertile | 6 | 54.46 (±28.61) | 6 | 23.67 (±6.24) | ||
| Alcohol | 111 | 123 | ||||
| 1st tertile | 36 | 51.81 (±22.65) | 0.96 | 37 | 24.67 (±8.42) | 0.64 |
| 2nd tertile | 41 | 52.54 (±25.46) | 46 | 27.65 (±25.55) | ||
| 3rd tertile | 34 | 51.13 (±24.97) | 40 | 28.59 (±17.90) | ||
| Methionine | 111 | 123 | ||||
| 1st tertile | 34 | 54.89 (±25.90) | 0.65 | 38 | 31.59 (±30.76) | 0.15 |
| 2nd tertile | 38 | 51.43 (±26.22) | 45 | 26.49 (±9.80) | ||
| 3rd tertile | 39 | 49.67 (±20.79) | 40 | 23.40 (±9.48) | ||
SD = standard deviation; DFE = dietary folate equivalent; 1 DFE diet = natural folate + 1.7 × (synthetic folate in diet); 2 DFE total = DFE diet + DFE supplement. Note: The first tertile represents the lower level of nutrient intake and the last tertile (3°) the highest level of nutrient intake.