Table 1.
miRNA molecules implicated in germ cell mitosis.
| Name | Expression | Proposed Function | Targets Involved in Mammalian Gametogenesis | Reference |
|---|---|---|---|---|
| miR-17-92 cluster | PGCs, ES cells | Regulator of differentiation, proliferation and apoptosis | STAT3, E2F1, PTEN | [110,118,119] |
| miRNA-31-5p | SSCs | Regulator of SSCs proliferation | JAZF1 and Cyclin A2 | [112] |
| miR-290-295 cluster |
PGCs | G1 to S phase cell cycle control | WEE1, FBXL5 | [110,113] |
| miR-202 | SSCs | Regulator of cell cycle and apoptosis of mitosis | Rbfox, Cpeb1 | [115] |
| miR-224 | SSCs | Control SSCs self-renewal and cyclical gene expression | DMRT1 | [117] |
| MiR-302-67 cluster |
PGCs | targeting inhibitors of the G1/S transition | Cdkn1a | [114,120] |
| miR-125a | Later male PGCs | Control of differentiation | LIN28 | [110] |
| miR-200c | Early PGCs | Control of apoptosis | ZEB1, TRKB | [110,121] |
| miR-21 | SSCs | SSCs self-renewal, anti-apoptosis | ZEB1, TRKB | [122] |
| miR-221 | PGCs | Regulate mitotic arrest in male germ cells | DND1 | [123] |
| miR-34c | PGCs | Cell cycle regulator | CCND3, CCNG1, CCNB1 NOTCH2 | [124,125] |