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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Gastroenterology. 2019 Mar 2;156(8):2297–2312. doi: 10.1053/j.gastro.2019.02.040

Figure 5.

Figure 5.

GNAI2 inhibits colitis but promotes CAC. (A) Body weight change of WT and GNAI2KO mice during the course of acute colitis with DSS (n = 12). (B–E) On day 10: (B) colitis severity score (n = 6), (C) change of the colon length, and (D) H&E representative images and histologic analysis of the colon of WT and GNAI2KO mice. Scale bars: upper, 100 μm; lower, 25 μm. (E–G) On day 63: (E) representative images of the colon and the change of the colon length, (F) tumor number/colon of indicated AOM–DSS-treated WT and GNAI2KO mice, and (G) H&E representative images of colonic tumors from WT and GNAI2KO mice. Scale bars: upper, 100 μm; lower, 25 μm. (H–J) On day 63: (H) representative images of the colon and the change of the colon length, (I) tumor number/colon of indicated AOM–DSS-treated WT and GNAI2cKO mice, and (J) H&E representative images of colonic tumors from number/colon of indicated AOM–DSS-treated WT and GNAI2cKO mice. Scale bars: upper, 100 μm; lower, 25 μm.