Table 3.

Physicochemical changes of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing 0.1 mg/mL curcumin. Particles were incubated for 24 h in serum at a volume ratio of 5:1. The hydrodynamic diameter is expressed as a measure of particle size distribution by intensity. All samples were measured in triplicates (n = 9, independent formulations) and data are expressed as means ± SD.

Time [h]	Diameter [nm]	PDI	ζ-potential [mV]
0	183.50 ± 2.11	0.19 ± 0.01	2.19 ± 0.49
1	180.80 ± 3.70	0.19 ± 0.01	−8.30 ± 0.21
4	180.45 ± 3.32	0.22 ± 0.01	−12.65 ± 0.35
24	173.57 ± 2.21	0.22 ± 0.01	−13.30 ± 0.10