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. 2019 Jun 21;24(12):2297. doi: 10.3390/molecules24122297

Table 1.

BNANC applications.

Organism Function or Disease Target Chemical Nature of Oligonucleotide Sequence of Active Oligomer Reference
A. baumannii Resistance to aminoglycosides aac(6′)-Ib BNANC/DNA conjugated to (RXR)4XB 1 (RXR)4XB-Cys-SMCC-C6 amino-cTgctGcgtAacaTc [94]
Cell lines Myotonic dystrophy type 1 DMPK 2 BNANC/DNA gapmer CGGAGcggttgtgaaCTGGC [95]
Murine, human cell lines, and mice Hypercholesterolemia PCSK9 3 BNANC/DNA mixmer CCaggCCTaTgagggTgCCg [92]
Human gene Hematologic malignancies DNTM3A 4 BNANC/DNA mixmers cgccaAgcgGctcatgtt
cgccAAgcagctcAtgtt
cgccAAgtgGctcAtgtt
cgccaAggggCtcatgtt
cgccAAgctgCtcAtgtt		 [96]
Human gene CRISPR-Cas9 specificity WAS 5 crRNA with BNANC substitutions uggauggagGAAugaggagu [97]
Human gene CRISPR-Cas9 specificity EXM1 6 crRNA with BNANC substitutions gaguccgagcaGAAgaagaa [97]

1 R, arginine; X, 6-aminohexanoic acid; B, β-alanine; 2 Dystrophia myotonica protein kinase; 3 Proprotein convertase subtilisin/kexin type 9; 4 Human DNA methyltransferase 3A; 5 Gene responsible for Wiskott-Aldrich Syndrome; 6 Homeobox protein EMX1.