Table 5.
Factors associated with gram-negative carbapenem-resistant bacterial infections.
| Carbapenem-Resistant Gram-Negative | P | |||
|---|---|---|---|---|
| Yes (n = 25) | No (n = 42) | |||
| Sex | Female | 10 (40.0%) | 25 (59.5%) | 0.122 |
| Male | 15 (60.0%) | 17 (40.5%) | ||
| Age (years) | 1.0 (2 month–18 years) | 1.0 (1 month–17 years) | 0.289 | |
| Duration of IMV support (days) | 23 (92.0%) | 28 (66.7%) | 0.019 | |
| Inotropic drug use | 9.0 (1–110) | 9.5 (1–52) | 0.559 | |
| Inotropic drug use | 10 (40.0%) | 25 (59.5%) | 0.122 | |
| Acute kidney injury | 6 (24.0%) | 15 (35.7%) | 0.320 | |
| Continuous renal replacement therapy | 3 (12.0%) | 10 (23.8%) | 0.237 | |
| NIV | 11 (44.0%) | 20 (47.6%) | 0.774 | |
| Duration of NIV support (h) | 48.0 (2–144) | 6.0 (1–96) | 0.083 | |
| Mortality | 6 (24.0%) | 7 (16.7%) | 0.463 | |
| Duration of PICU stay (days) | 11.0 (1–120) | 7.5 (1–52) | 0.031 | |
| Intravenous immunoglobulin use | 6 (24.0%) | 17 (40.5%) | 0.275 | |
| Previous hospitalization | 23 (92.0%) | 30 (71.4%) | 0.045 | |
| Surgery | 3 (12.0%) | 3 (7.1%) | 0.501 | |
| Red blood cell transfusion | 12 (48.0%) | 35 (83.3%) | 0.007 | |
| Central venous catheter use | 19 (76.0%) | 33 (78.6%) | 0.807 | |
| Total parenteral nutrition usage before infection | 19 (76.0%) | 15 (35.7%) | <0.001 | |
| Positive culture samples taken at admission | 20 (80.0%) | 36 (85.7%) | 0.541 | |
| Culture results | Klebsiella spp. | 9 (36.0%) | 18 (42.9%) | <0.001 |
| P. aeruginosa | 8 (32.0%) | 7 (16.7%) | ||
| Acinetobacter spp. | 6 (24.0%) | 1 (2.4%) | ||
| Others | 2 (8.0%) | 16 (38.1%) | ||
| Culture sample source: Antibiotics used for salvage treatment in addition to IV colistin treatment |
Tracheal aspirate | 17 (68.0%) | 12 (28.6%) | 0.007 |
| Blood | 6 (24.0%) | 22 (52.4%) | ||
| Others | 2 (8.0%) | 8 (19.0%) | ||
| Tigecycline | 9 (36.0%) | - | ||
| Rifampin | 11 (44.0) | - | ||
| Nebulised colistin | 23 (92.0%) | - | ||
Values are reported as number (percentage) or median (range). PICU, paediatric intensive care unit; IMV, invasive mechanical ventilation, NIV, non-invasive mechanical ventilation.