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. 2019 May 31;11(6):501. doi: 10.3390/v11060501

Table 2.

Time to the most recent common ancestor (TMRCA) estimates of HPAI H5N5 genotypes. Estimated median TMRCA for each gene segment of highly pathogenic avian influenza (HPAI) H5N5 viruses of genotype H5N5-GT2, the European H5N5-GT2 viruses and H5N5-GT3 viruses with 95% highest posterior density (HPD) intervals. The nodes for which the median TMRCAs estimates were determined are depicted in the time-scaled phylogenetic trees in Figure S3. PB2, polymerase basic protein 2; PB1, polymerase basic protein 1; PA, polymerase acidic protein; HA, hemagglutinin; NP, nucleoprotein; NA, neuraminidase; MP, matrix protein; NS, nonstructural protein.

H5N5-GT2 Viruses (Node 1) European H5N5-GT2 Viruses (Node 2) H5N5-GT3 Viruses (Node 3)
Gene Segment Median TMRCA Lower 95% HPD Upper 95% HPD Posterior Median TMRCA Lower 95% HPD Upper 95% HPD Posterior Median TMRCA Lower 95% HPD Upper 95% HPD Posterior
PB2 Mar-2016 Aug-2015 Aug-2016 0.9997 Sep-2016 May-2016 Nov-2016 0.9997 Oct-2016 Aug-2016 Nov-2016 0.4823
PB1 Dec-2015 Apr-2015 Jun-2016 0.9983 Jul-2016 Feb-2016 Oct-2016 0.9982 Oct-2016 May-2016 Jan-2017 0.9971
PA Aug-2016 Jun-2016 Sep-2016 0.9982 Oct-2016 Sep-2016 Nov-2016 0.9995 Nov-2016 Oct-2016 Dec-2016 0.0942
HA Jun-2016 Jan-2016 Aug-2016 0.9995 Oct-2016 Oct-2016 Jun-2016 0.9991 Dec-2016 Oct-2016 Jan-2017 0.9991
NP Mar-2016 Aug-2015 Aug-2016 0.9988 Aug-2016 Apr-2016 Aug-2016 0.9988 Sep-2016 Mar-2016 Dec-2016 0.9991
NA Nov-2015 Apr-2015 May-2016 0.9997 Apr-2016 Nov-2015 Aug-2016 0.9929 Oct-2016 Jun-2016 Jan-2017 0.9713
MP Aug-2016 Jun-2016 Sep-2016 0.9929 Nov-2016 Nov-2016 Dec-2016 0.9928 Jan-2017 Dec-2016 Jan-2017 0.0325
NS Jul-2016 Mar-2016 Sep-2016 0.9992 Nov-2016 Jun-2016 Aug-2016 0.9835 Dec-2016 Nov-2016 Dec-2016 0.0038