Table 1.

Characteristics of three patients with ICF2.

Patient	Sex	Year of Birth	Age at First Diagnosis of PID/First Immunological Evaluation	Facial Anomalies	Motor Development	Intellectual Development	Infections	Other
P1	M	1992	3	broad flat nasal bridge, micrognathia	normal	Attention deficit hyperactivity disorder, treatment with methylphenidate till the 15th year of life, otherwise normal, work without difficulty	sepsis after birth, three pneumonias (H. influenzae), recurrent upper respiratory tract infections (bronchitis, otitis media, sinusitis)	atopic dermatitis
P2	F	1996	7	broad flat nasal bridge	normal	Selective mutism in early childhood, otherwise normal, work without difficulty	Atypical mycobacteriosis, recurrent shingles, prolonged fever after vaccination with MMR	atopic dermatitis, scoliosis, nail clubbing, focal bronchial malformation with absence of bronchial glands and cartilage
P3	F	1996	7	broad flat nasal bridge	normal	Selective mutism in early childhood, otherwise normal, work without difficulty	none	atopic dermatitis, idiopathic epileptic seizures