Figure 2.

Potential host and viral targets of antiviral drugs. Antiviral therapy against HEV can rely on the inhibition and manipulation of host components, which are important for the HEV life cycle. Additionally, direct acting antiviral specifically can target viral enzymes (e.g., helicase, polymerase, protease) without affecting host components. Notably, the nucleoside analog Ribavrin is reported to exert antiviral effects by targeting both the virus and the host [19].