Table 1.
Summary of polymeric nanoparticle (NP) prepared with varying levels of surface modification.
| Formulation | Active Stabilizer | Stabilizer | Inert Core | NP Properties | ||||
|---|---|---|---|---|---|---|---|---|
| Block co-polymer | Conc. (mg/mL) | Block co-polymer | Conc. (mg/mL) | Filler | Conc. (mg/mL) | Z-diameter (nm) 1 | PDI 2 | |
| 0% | PS-b-PEG-Gal | 0.00 | PS-b-PEG | 0.40 | VitE | 0.40 | 88.83 ± 4.64 | 0.0327 |
| 25% Gal-NP | PS-b-PEG-Gal | 0.10 | PS-b-PEG | 0.30 | VitE | 0.40 | 73.78 ± 2.23 | 0.0132 |
| 50% Gal-NP | PS-b-PEG-Gal | 0.20 | PS-b-PEG | 0.20 | VitE | 0.40 | 74.74 ± 2.26 | 0.0083 |
| 100% Gal-NP | PS-b-PEG-Gal | 0.40 | PS-b-PEG | 0.00 | VitE | 0.40 | 81.47 ± 12.75 | 0.2693 |
1 Data represent the mean with error described as the standard error of means of at least three independent preparations of the particles, each with three instrumental replicates. 2 Polydispersity Index (PDI) = (standard deviation/mean diameter)^2. Abbreviations: VitE, vitamin E (α-tocopherol).