Table 1.
Effects of injected and aerosolized synthetic cannabinoids in mice trained to discriminate 5.6 mg/kg THC from vehicle
| Intraperitoneal Injection | Aerosol | |||
|---|---|---|---|---|
| ED50 (mg/kg) (± 95% CI) |
EC50 (mg/ml) (± 95% CI) |
|||
| Test substance CB1 receptor affinitya |
Males | Females | Males | Females |
|
THC CB1 Ki = 50 nMb |
1.50 (1.20 – 1.89) |
1.55 (1.23 – 1.94) |
Not tested | Not tested |
|
CP55,940 CB1 Ki = 1.74 nMc |
0.03 (0.03 – 0.04) |
0.06 (0.05 – 0.07) |
6.00 (3.92 – 9.17) |
7.32 (5.63 – 9.51) |
|
AB-CHMINACA CB1 Ki = 0.78 nMd |
0.09 (0.07 – 0.13) |
0.08 (0.06 – 0.10) |
3.67 (3.38 – 3.99) |
5.62 (4.99 – 6.32) |
|
AMB-FUBINACA CB1 Ki = 2 nMb |
0.04 (0.03 – 0.05) |
0.07 (0.06 – 0.09) |
0.39 (0.32 – 0.46) |
0.94 (0.74 – 1.20) |
|
Cumyl-4CN-BINACA CB1 Ki = 8.58 nMb |
Not tested | Not tested | Not tested | 1.86 (1.21 – 2.84) |
a
[3H]CP55,940 was used as ligand for all CB1 binding assays.
b
Personal communication (Michelle Glass, University of Otago, New Zealand). Binding affinities were obtained using methods described in (Banister et al., 2019).