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. 2019 Jul 8;8:e46156. doi: 10.7554/eLife.46156

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© 2019, Argyropoulos et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 1. — We first (1) identified cognitive deficits by comparing patients with healthy controls in a broad range of tests of neuropsychological assessment. We identified regions in which patients showed (2) reduced gray matter volumes and (3) resting-state functional connectivity and activity relative to healthy controls; (4) we also identified relationships between structural/functional abnormalities and performance in tests in which patients showed impairment as compared with healthy controls; 'connectome-MVPA': connectome ‘multi-variate pattern analysis’ (Whitfield-Gabrieli and Nieto-Castanon, 2012); MRI: Magnetic Resonance Imaging; MTL: medial temporal lobe; n: number of participants; rsALFF: resting-state amplitude of low-frequency fluctuations; rsFC: resting-state functional connectivity; VBM: voxel-based morphometry.