Skip to main content
. 2019 Jul 8;8:e46156. doi: 10.7554/eLife.46156

Figure 8. Remote Autobiographical Memory: Structural/Functional correlates.

Figure 8.

(a) GM volume of the left HPC VBM cluster correlated with the left thalamic volume across patients; (b) remote autobiographical memory (AMI) scores correlated across patients with the volume of the left thalamus, surviving correction across the 13 structural/functional abnormalities examined (r = 0.558, p-corr = 0.015); the mediation analysis demonstrates that this effect held when the correlation of thalamic volume with the volume expressed by the left HPC VBM cluster was accounted for; (c) the volume expressed by the left HPC VBM cluster correlated with remote autobiographical memory scores, albeit this correlation did not survive correction for multiple testing (r = 0.467, p-corr = 0.096); the mediation analysis demonstrated that this relationship did not hold over and above the correlation of the left thalamic volume with the HPC clusters; there was thus no direct effect of reduced HPC GM volume on remote autobiographical memory (within parenthesis: 95% confidence intervals); ‘18’: remote autobiographical memory scores are the sums of the AMI scores for autobiographical memories for childhood and early adulthood (max = 18); AMI: Autobiographical Memory Interview; GM: gray matter; HPC: hippocampus; MAP: Memory and Amnesia Project; OPTIMA: Oxford Project To Investigate Memory and Aging; p: significance values are presented at uncorrected levels; TIV: total intracranial volume; VBM: voxel-based morphometry; z-res: volumes are residualized against age, sex, scan source (MAP, OPTIMA) and TIV across participants.

Figure 8—source data 1. This spreadsheet contains the mean GM volume of the left HPC VBM cluster and the volume of the automatically delineated left thalamus (z-res) and the remote autobiographical memory scores [max = 18; Autobiographical Memory Interview; (Kopelman et al., 1989)] of healthy controls and patients (over the age of 50 at the time of assessment; See Materials and methods section) that are plotted in Figure 8; GM: gray matter; HPC: hippocampus; MAP: Memory and Amnesia Project; OPTIMA: Oxford Project To Investigate Memory and Aging; VBM: voxel-based morphometry; z-res: volumes are residualized against age, sex, scan source (MAP, OPTIMA), and TIV across participants. These data can be opened with Microsoft Excel or with open-source alternatives such as OpenOffice.
elife-46156-fig8-data1.xlsx (15.2KB, xlsx)
DOI: 10.7554/eLife.46156.020