Figure 5.

In vivo detection of endothelial injury using molecular imaging. (a) Schematic of in vivo molecular imaging approach; (b) Representative SLO-micrographs from the retinas of normal and diabetic animals. White dots represent firmly adhering probes; (c) In vivo probe adhesion in normal and three-week diabetic animals (n = 5, ** p < 0.01); (d) Molecular imaging of retinal endothelial ICAM-1 in 6 diabetic animals (n = 6, ** p < 0.01); (e) Comparison between the binding of two differently sized -ICAM-1 imaging probes (1 and 2 μm) in diabetic retinas (n = 5).