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. 2019 Jul 9;9(16):4795–4810. doi: 10.7150/thno.30988

Figure 1.

Figure 1

CF129 is downregulated in pancreatic cancer and associated with worse clinical results (A) Hierarchical clustering assessment of lncRNAs differentially expressed between normal pancreatic (NP) and pancreatic cancer (PC) tissues, which include lncRNA CF129145.1 (CF129). (B) qRT-PCR analysis of CF129 expression in 40 pairs PC and paired adjacent NP tissues. (C) CF129 expression was further compared among HPDC cells and the BxPC-3, PANC-1, and SW1990 cell lines. (D) Prediction of CF129 second structure from the database LNCipedia. Coloration indicates prediction confidence, we red corresponding to a higher degree of confidence. (E) The noncoding nature of CF129 was predicted by multiple databases from LNCipedia. (F) Total nuclear and cytoplasmic PANC-1 RNA was assessed, with relative nuclear and cytoplasmic RNA abundance shown following qRT-PCR assessment. (G) Single molecule RNA FISH detection of CF129 (green) in indicated PANC-1/BxPC-3 cells. DAPI was used to stain nuclei. Scale bars: 20μm. (H) The overall survival in 40 PC patients as assessed via Kaplan-Meier curves. The cut-off for determination of high/low CF129 expression was the median overall expression level. Groups were compared via Log-rank test.