Skip to main content
. 2019 Jul 9;9(16):4740–4755. doi: 10.7150/thno.33520

Figure 1.

Figure 1

Schematic illustration of the preparation of MV-DEX and the therapeutic effects of MV-DEX against renal diseases. RAW macrophages were treated with DEX and then supernatants were collected for MV isolation by centrifugation. MV-DEX treatment improved renal function, alleviated renal inflammation and fibrosis, and reduced side effects to a greater magnitude than free DEX. Mechanistically, MV-DEX efficiently targeted inflamed kidney through LFA-1 and VLA-4 on the surface. Further, MV-DEX increased the cellular levels of the GR and facilitated the entry of DEX into the cells.