. 2019 Jun 6;10(7):1068–1081. doi: 10.1039/c9md00018f

Table 1. Albumin-binding small organic compounds.

Cargo		Albumin-binding molecule	Conjugate		Factor	Ref.
Type	τ _1/2	Albumin-binding molecule	Affinity	τ _1/2	Factor	Ref.
fVIIa inhibitor^†	7.6 min (i.v.)^a	Naphthalene acylsulfonamide	n.a.	30 min (i.v.)^a	4^a	36
fVIIa inhibitor^†	4.2 min (i.v.)^a	Diphenylcyclohexanol phosphate ester	n.a.	222 min (i.v.)^a	53^a	37
Insulin^†	3.3 h (i.v.)^b	Fmoc derivative with a 16-sulfanyl hexadecanoic acid	3.9^c μM*	17 h (i.v.)^b	5^b	40
Exendin-4^†	2.8 h (s.c.)^b	Dicoumarol derivative with maleimide	n.a.	19–22 h (s.c.)^b	7–8^b	41
Exendin-4^†	5.2 h (s.c.)^d	Evans blue derivative with maleimide	n.a.	36.3 h (s.c.)^d	7^d	43
GLP-1^†	n.a.	Diflunisal-γGlu-Lys(±O2Oc)-indomethacin	n.a.	5 h (s.c.)^d	Liraglutide 4.4 h (s.c.)^d	46
scFv^§	20–30 min (i.v.)^d	6-(4-(p-Iodophenyl) butanamido) hexanoate	3.2^c, 3.6^d μM	16.6 h (i.v.)^d	33–50^d	52
Fluorescein^‡	4.6 min (i.v.)^d		108^c, 118^d nM^#	495 min (i.v.)^d	108^d	48
Fluorescein^‡	4.6 min (i.v.)^d		330^c nM^$	495 min (i.v.)^d	108^d
Gd-DTPA^‡	8.6 min (i.v.)^d		3.3^c μM	408 min (i.v.)^d	47^d