Table 2. Albumin-binding peptide ligands.
Cargo |
Albumin-binding molecule | Conjugate |
Factor | Ref. | ||
Type | τ 1/2 | Affinity | τ 1/2 | |||
Anti-HER2§ | 4.3 h (i.v.)a | 89D03 (15b nM) | n.a. | Single copy: 31.2 h (i.v.)a | 7a | 65 |
Double copy: 84.5 h (i.v.)a | 20a | |||||
huPA inhibitor† | 18 min (i.v.)c | F-tag (39b, 220c, 320d nM) | 168b, 780c nM | 7.4 h (i.v.)c | 25c | 62 |
hFXIIa inhibitor† | 13 min (i.v.)d | 224a, 1600d nM | 5.2 h (i.v.)d | 24d | ||
Fab§ | 53 min (i.v.)d | SA21 (467b, 266c, 320d, 7e nM) | 320d nM | 32.4 h (i.v.)d | 37d | 60 |
24 min (i.v.)e | 10.4 h (i.v.)e | 26e | ||||
huPA inhibitor† | 30 min (i.v.)e | 354b, 14e nM | 24 h (i.v.)e | 48e | 67 | |
Exendin-4† | 30 min (i.v.)c | 610a, 1560b, 210c nM | 2 d (i.v.)a | 22c | 83 | |
11 h (i.v.)c |