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. 2007 Feb 26;30(2):69–74. doi: 10.1002/clc.19

Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE)

Timothy R Wessel 1, Christopher B Arant 1, Susan P McGorray 1, Barry L Sharaf 2, Steven E Reis 3, Richard A Kerensky 1, Gregory O von Mering 1, Karen M Smith 1, Daniel F Pauly 1, Eileen M Handberg 1, Sunil Mankad 4, Marian B Olson 3, B Delia Johnson 3, C Noel Bairey Merz 5, George Sopko 6, Carl J Pepine 1,✉
PMCID: PMC6653045  PMID: 17326061

Abstract

Background

Altered coronary reactivity is frequent in women with findings of myocardial ischemia without significant obstructive disease. This suggests a defect in coronary microvascular function. The adenosine‐related component of this altered reactivity has been described in male and mixed gender populations, while the factors influencing this component of coronary reactivity in symptomatic women have received limited attention. Accordingly, the relationship between adenosine‐related microvascular coronary reactivity and risk factors in symptomatic women evaluated for suspected ischemia remains uncertain.

Hypothesis

Abnormal coronary microvascular reactivity to adenosine is predicted by atherosclerosis risk factors in women.

Methods

As part of the NHLBI‐sponsored Women's Ischemia Syndrome Evaluation (WISE), we investigated the relationship between risk factors and coronary microvascular reactivity as flow velocity reserve to intracoronary adenosine (CFVRAdo) in 210 women referred for angiography to evaluate suspected ischemia.

Results

Univariate analyses identified associations between CFVRAdo and multiple risk conditions; however, after adjusting for age, none remained significant. The best multivariable model using combinations of risk conditions to predict CFVRAdo yielded an R2 of only 0.18.

Conclusions

Among women with suspected ischemia, risk factors account for <20% of observed variability in CFVRAdo. Therefore, other as yet unidentified factors must primarily account for coronary microvascular reactivity to adenosine. Copyright © 2007 Wiley Periodicals, Inc.

Keywords: women, risk factors, microcirculation, adenosine

Full Text

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