Abstract
Sertraline is a selective serotonin reuptake inhibitor with established safety for the treatment of depression. Among the common adverse effects associated with sertraline are nausea, insomnia, diarrhea, somnolence, and dizziness. Cardiac arrest had not been reported in the literature, although tachycardia was frequently seen. In this case report, a patient was presented who had adverse reactions such as nausea, dizziness, insomnia under citalopram treatment, and after his drug was changed to sertraline, developed sinus arrest on the fourth day of treatment. Copyright © 2010 Wiley Periodicals, Inc.
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References
- 1. Hersh EV, Pinto A, Moore PA. Adverse drug interactions involving common prescription and over‐the‐counter analgesic agents. Clin Ther 2007; (suppl)29: 2477–2497. [DOI] [PubMed] [Google Scholar]
- 2. Hoehns JD, Fouts MM, Kelly MW, et al. Sudden cardiac death with clozapine and sertraline combination. Ann Pharmacother 2001; 35: 862–866. [DOI] [PubMed] [Google Scholar]
- 3. Lenk MK, Alehan D, Ozme S, et al. Vasovagal syncope: asystole provoked by head‐up tilt testing under sertraline therapy. Turk J Pediatr 1997; 39: 573–577. [PubMed] [Google Scholar]
- 4. Gury C, Cousin F. Pharmacokinetics of SSRI antidepressants: half‐life and clinical applicability. Encephale 1999; 25: 470–476. [PubMed] [Google Scholar]
- 5. Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother 2007; 41: 674–680. [DOI] [PubMed] [Google Scholar]
- 6. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239–245. [DOI] [PubMed] [Google Scholar]
- 7. Hjorth S, Auerbach SB. Autoreceptors remain functional after prolonged treatment with a serotonin reuptake inhibitor. Brain Res 1999; 835: 224–228. [DOI] [PubMed] [Google Scholar]