Abstract
A 51‐year‐old woman presented with severe chest pain minutes after starting intravenous paclitaxel as a part of the systemic chemotherapy due to ovarian carcinoma. The electrocardiogram (ECG) revealed sinus rhythm with ST‐segment elevations in inferior and anterior leads. The ST‐segment elevations resolved immediately after sublingual nitroglycerine. Cardiac troponin T and CPK MB levels remained in the normal range at repeat measurements. It was presumed that in spite of standard premedication, paclitaxel had induced acute coronary syndrome with ST‐segment elevations in this patient. Copyright © 2009 Wiley Periodicals, Inc.
Full Text
The Full Text of this article is available as a PDF (2.9 MB).
References
- 1. Markman M. New, expanded, and modified use of approved antineoplastic agents in ovarian cancer. Oncologist. 2007; 12: 186–190. [DOI] [PubMed] [Google Scholar]
- 2. Markman M, Kennedy A, Webster K, Kulp B, Peterson G, et al. Paclitaxel‐associated hypersensitivity reactions: experience of the gynecologic oncology program of the Cleveland Clinic Cancer Center. J Clin Oncol. 2000; 18: 102–105. [DOI] [PubMed] [Google Scholar]
- 3. Sendo T, Sakai N, Itoh Y, Ikesue H, Kobayashi H, et al. Incidence and risk factors for paclitaxel hypersensitivity during ovarian cancer chemotherapy. Cancer Chemother Pharmacol. 2005; 56: 91–96. [DOI] [PubMed] [Google Scholar]
- 4. Nguyen‐Ho P, Kleiman NS, Verani MS. Acute myocardial infarction and cardiac arrest in a patient receiving paclitaxel. Can J Cardiol. 2003; 19: 300–302. [PubMed] [Google Scholar]
- 5. Schrader C, Keussen C, Bewig B, von Freier A, Lins M. Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with Paclitaxel (Taxol) in a patient with meta‐ static ovarian carcinoma. Eur J Med Res. 2005; 10: 498–501. [PubMed] [Google Scholar]
