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References
- 1. Libby P: Inflammation in atherosclerosis. Nature 2002; 420 (6917): 86–74 [DOI] [PubMed] [Google Scholar]
- 2. Forrester JS: Prevention of plaque rupture: A new paradigm of therapy. Ann Intern Med 2002; 137 (10): 823–833 [DOI] [PubMed] [Google Scholar]
- 3. Lang CH, Dobrescu C, Bagby GJ: Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992; 130 (1): 43–52 [DOI] [PubMed] [Google Scholar]
- 4. Rotter V, Nagaev I, Smith U: Interleukin‐6 (IL‐6) induces insulin resistance in 3T3‐L1 adipocytes and is, like IL‐8 and tumor necrosis factor‐alpha, over‐expressed in human fat cells from insulin‐resistant subjects. J Biol Chem 2003; 278 (46): 45777–45784 [DOI] [PubMed] [Google Scholar]
- 5. Mathis D, Vence L, Benoist C: Beta‐cell death during progression to diabetes. Nature 2001; 414 (6865): 792–798 [DOI] [PubMed] [Google Scholar]
- 6. Ridker PM, Buring JE, Cook NR, Rifai N: C‐reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8‐year follow‐up of 14,719 initially healthy American women. Circulation 2003; 107 (3): 391–397 [DOI] [PubMed] [Google Scholar]
- 7. Gonzalez MA, Selwyn AP: Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med 2003; 115 (suppl 8A): 99S–106S [DOI] [PubMed] [Google Scholar]
- 8. Wilson CJ, Finch CE, Cohen HJ: Cytokines and cognition‐the case for a head‐to‐toe inflammatory paradigm. J Am Geriatr Soc 2002; 50 (12): 2041–2056 [DOI] [PubMed] [Google Scholar]
- 9. Katsuse O, Iseki E, Kosaka K: Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with dementia with Lewy bodies. Neuropathology 2003; 23 (1): 9–15 [DOI] [PubMed] [Google Scholar]
- 10. Kempermann G, Neumann H: Neuroscience. Microglia: The enemy within? Science 2003; 302 (5651): 1689–1690 [DOI] [PubMed] [Google Scholar]
- 11. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ: Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia Aging Study. Ann Neurol 2002; 52 (2): 168–174 [DOI] [PubMed] [Google Scholar]
- 12. Mann DL: Inflammatory mediators and the failing heart: Past, present, and the foreseeable future. Circ Res 2002; 91 (11): 988–998 [DOI] [PubMed] [Google Scholar]
- 13. Sivasubramanian N, Coker ML, Kurrelmeyer KM, MacLellan WR, DeMayo FJ, Spinale FG, Mann DL: Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation 2001; 104: 826–831 [DOI] [PubMed] [Google Scholar]
- 14. Li YY, Feng YQ, Kadokami T, McTiernan CF, Draviam R, Watkins SC, Feldman AM: Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti‐tumor necrosis factor α therapy. Proc Natl Acad Sci USA 2000; 97: 12746–12751 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15. Knittel T, Mehde M, Grundmann A, Saile B, Scharf JG, Ramadori G: Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Histochem Cell Biol 2000; 113: 443–453 [DOI] [PubMed] [Google Scholar]
- 16. Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J: Transfer of tumor necrosis factor‐α to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor‐β1 and myofibroblasts. Am J Pathol 1998; 153: 825–832 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17. Agnoletti L, Curello S, Bachetti T, Malacarne F, Gaia G, Comini L, Volterrani M, Bonetti P, Parrinello G, Cadei M, Grigolato PG, Ferrari R: Serum from patients with severe heart failure downregulates eNOS and is proapoptotic: Role of tumor necrosis factor‐α. Circulation 1999; 100: 1983–1991 [DOI] [PubMed] [Google Scholar]
- 18. Oral H, Sivasubramanian N, Dyke DB, Mehta RH, Grossman, Briesmeister K, Fay WP, Pagani FD, Bolling SF, Mann DL, Starling MR: Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation. Circulation 2003; 107: 831–837 [DOI] [PubMed] [Google Scholar]
- 19. Ware CF, Van Arsdale S, Van Arsdale TL: Apoptosis mediated by the TNF‐related cytokine and receptor families. J Cell Biochem 1996; 60 (1): 47–55 [DOI] [PubMed] [Google Scholar]
- 20. Nilsen‐Hamilton M: Transforming growth factor‐beta and its actions on cellular growth and differentiation. Curr Top Dev Biol 1990; 24: 95–136 [PubMed] [Google Scholar]
- 21. Hiura M, Kikuchi T, Nagasaki K, Uchiyama M: Elevation of serum C‐reactive protein levels is associated with obesity in boys. Hypertens Res 2003; 26 (7): 541–546 [DOI] [PubMed] [Google Scholar]
- 22. Tchernof A, Nolan A, Sites CK, Ades PA, Poehlman ET: Weight loss reduces C‐reactive protein levels in obese postmenopausal women. Circulation 2002; 105 (5): 564–569 [DOI] [PubMed] [Google Scholar]
- 23. Ford ES: Does exercise reduce inflammation? Physical activity and C‐reactive protein among U. S. adults. Epidemiology 2002; 13 (5): 561–568 [DOI] [PubMed] [Google Scholar]
- 24. Knowler WC, Barrett‐Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, and the Diabetes Prevention Program Research Group : Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346 (6): 393–403 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25. Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003; 348 (5): 383–393 [DOI] [PubMed] [Google Scholar]
- 26. Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, Freed MI: Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 2002; 106 (6): 679–684 [DOI] [PubMed] [Google Scholar]
- 27. Buchanan TA, Xiang AH, Peters RK, Kjos SL, Marroquin A, Goico J, Ochoa C, Tan S, Berkowitz K, Hodis HN, Azen SP: Preservation of pancreatic beta‐cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high‐risk Hispanic women. Diabetes 2002; 51 (9): 2796–2803 [DOI] [PubMed] [Google Scholar]
- 28. Mach F: Statins as novel immunomodulators: From cell to potential clinical benefit. Thromb Haemost 2003; 90 (4): 607–610 [DOI] [PubMed] [Google Scholar]
- 29. Collins R, Armitage J, Parish S, Sleigh P, Peto R, and the Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of cholesterol‐lowering with simvastatin in 5,963 people with diabetes : A randomised placebo‐controlled trial. Lancet 2003; 361 (9374): 2005–2016 [DOI] [PubMed] [Google Scholar]
- 30. Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA: Statins and the risk of dementia. Lancet 2000; 356 (9242): 1627–1631 [DOI] [PubMed] [Google Scholar]
- 31. Rockwood K, Kirkland S, Hogan DB, MacKnight C, Merry H, Verreault R, Wolfson C, McDowell I: Use of lipid‐lowering agents, indication bias, and the risk of dementia in community‐dwelling elderly people. Arch Neurol 2002; 59 (2): 223–227 [DOI] [PubMed] [Google Scholar]
- 32. Stuve O, Youssef S, Steinman L, Zamvil SS: Statins as potential therapeutic agents in neuroinflammatory disorders. Curr Opin Neurol 2003; 16 (3): 393–401 [DOI] [PubMed] [Google Scholar]
- 33. Youssef S: The HMG‐CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002; 420 (6911): 78–84 [DOI] [PubMed] [Google Scholar]
- 34. Node K, Fujita M, Kitakaze M, Hori M, Liao JK: Short‐term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation 2003; 108 (7): 839–843 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 35. Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL: Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 2003; 302 (5648): 1223–1227 [DOI] [PubMed] [Google Scholar]
- 36. Hayakawa Y, Chandra M, Miao W, Shirani J, Brown JH, Dorn GW II, Armstrong RC, Kitsis RN: Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation 2003; 108 (24): 3036–3041 [DOI] [PubMed] [Google Scholar]
