Abstract
Background: Erectile dysfunction (ED) and cardiovascular disease share common risk factors and may be further aggravated by medical treatment for reducing them.
Hypothesis: The study was undertaken to assess the prevalence of ED in patients with diabetes (DM), hypertension (HTN), or both diseases, and to evaluate the effect of patient age, medical treatment, and disease duration and control on the prevalence of ED in tins population.
Methods; A group of 150 primary practitioners who had patients with known DM and or HTN conducted a survey. utilizine IIEF‐15, a 15‐itemmultidunensional. self‐admnistered questionnaire used for the clinical assessment of ED.
Results: In all, 1,412 patients were included: 37%liadDM, 38% had HTN, and 25% had both diseases. Then mean age was 55,58, and 60 yean, and 62,46, and 67% had some degree of ED, respectively The prevalence of ED increased with age and disease duration m each age group and was higher in subjects with DM than in those with HTN, especially in those aged < 65 years. Poor glycemic control was associated with a higher prevalence rate of ED early in the course of the disease. There was no significant difference in the prevalence of ED according to type and number of antihypertensive drugs.
Conclusions: Erectile dysfunction is common among patients at high risk for cardiovascular disease because of diabetes and or HTN. Diabetic men are affected earlier than those wife HTN. Given the high frequency of ED in young patients wife these risk tartars, physicians should encourage an open discussion on the subject during routine visits to promote early detection and treatment.
Keywords: hypertension, diabetes, erectile dysfunction
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References
- 1. NIH Consensus Development Panel on Impotence : NIH Consensus Conference: Impotence. J Am Med Assoc 1993; 270: 83–90 [PubMed] [Google Scholar]
- 2. Benet AE, Melman A: The epidemiology of erectile dysfunction. Urol Clin North Am 1995; 22: 699–709 [PubMed] [Google Scholar]
- 3. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB: Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61 [DOI] [PubMed] [Google Scholar]
- 4. Shabsigh R: Is a drug effect part of your patient's complaint of impotence? Contemp Urol 1993; 5: 51–58 [Google Scholar]
- 5. Finger WW, Lung M, Stagle MA: Medications that may contribute to sexual disorders. J Fam Pract 1997; 44: 33–43 [PubMed] [Google Scholar]
- 6. Lue TF: Drug therapy: Erectile dysfunction. N Engl J Med 2000; 342: 1802–1813 [DOI] [PubMed] [Google Scholar]
- 7. Sullivan ME, Thompson CS, Dashwood MR, Khan MA, Jeremy JY, Morgan RJ, Mikhailidis DP: Nitric oxide and penile erection: Is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res 1999; 43: 658–665 [DOI] [PubMed] [Google Scholar]
- 8. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A: The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997, 49: 822–830 [DOI] [PubMed] [Google Scholar]
- 9. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH: Diagnostic evaluation of the erectile function domain of the international index of erectile function. Urology 1999, 54: 346–351 [DOI] [PubMed] [Google Scholar]
- 10. Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinaly JB: Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts Male Aging Study. J Urol 2000; 163: 460–463 [PubMed] [Google Scholar]
- 11. Melman A, Gingell JC: The epidemiology and pathophysiology of erectile dysfunction. J Urol 1999; 161: 5–11 [PubMed] [Google Scholar]
- 12. Romeo JH, Seftel AD, Madhun ZT, Aron DC: Sexual function in men with diabetes type 2: Association with glycemic control. J Urol 2000; 163: 788–791 [PubMed] [Google Scholar]
- 13. Newman HF, Marcus H: Erectile dysfunction in diabetes and hypertension. Urology 1985; 26: 135–137 [DOI] [PubMed] [Google Scholar]
- 14. Klein R, Klein BE, Lee KE, Moss SE, Cruickshanks KJ: Prevalence of self‐reported erectile dysfunction in people with long‐term IDDM. Diabetes Care 1996; 19: 135–141 [DOI] [PubMed] [Google Scholar]
- 15. Masters WH, Johnson VE: Sex after sixty‐five. Reflections 1977; 12: 31–43 [Google Scholar]
- 16. Virag R, Bouilly P, Frydman D: Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1985; 1: 181–184 [DOI] [PubMed] [Google Scholar]
- 17. Chew KK, Earle CM, Stuckey BG, Jamrozik K, Keogh EJ: Erectile dysfunction in general medicine practice: Prevalence and clinical correlates. Int J Impot Res 2000; 12: 41–45 [DOI] [PubMed] [Google Scholar]
- 18. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA: Impaired neurogenic and endothelium‐mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989; 320: 1025–1030 [DOI] [PubMed] [Google Scholar]
- 19. Kadioglu A, Erdogru T, Karsidag K, Dinccag N, Satman I, Yilmaz MT, Tellalogu S: Evaluation of penile arterial system with color Doppler ultra‐sonography in nondiabetic and diabetic males. Eur Urol 1995; 27: 311–314 [DOI] [PubMed] [Google Scholar]
- 20. Metro MJ, Broderick GA: Diabetes and vascular impotence: Does insulin dependence increase the relative severity? Int J Impot Res 1999; 11: 87–89 [DOI] [PubMed] [Google Scholar]
- 21. Rajfer J, Rosciszewski A, Mehringer M: Prevalence of corporeal venous leakage in impotent men. J Urol 1988; 140: 69–71 [DOI] [PubMed] [Google Scholar]
- 22. Colakoglu Z, Kutluay E, Ertekin C, Altay B, Killi R, Alkis A: Autonomic nerve involvement and venous leakage in diabetic men with impotence. BJU Int 1999; 83: 453–456 [DOI] [PubMed] [Google Scholar]
- 23. Rowland DL, Greenleaf W, Mas M, Myers L, Davidson JM: Penile and finger sensory thresholds in young, aging, and diabetic males. Arch Sex Behav 1989; 18: 1–12 [DOI] [PubMed] [Google Scholar]
- 24. Christ GJ, Maayani S, Valcic M, Melman A: Pharmacological studies of human erectile tissue: Characteristics of spontaneous contractions and alterations in alpha‐adrenoceptor responsiveness with age and disease in isolated tissues. Br J Pharmacol 1990; 101: 375–381 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25. Sartucci F, Piaggesi A, Logi F, Bonfiglio L, Bongioanni P, Pellegrinetti A, Baccetti F, Navalesi R, Murri L: Impaired ascendant central pathways conduction in impotent diabetic subjects. Acta Neurol Scand 1999; 99: 381–386 [DOI] [PubMed] [Google Scholar]
- 26. Autieri MV, Melman A, Christ GJ: Identification of a down‐regulated mRNA transcript in corpus cavernosum from diabetic patients with erectile dysfunction. Int J Impot Res 1996; 8: 69–73 [PubMed] [Google Scholar]
- 27. Hakim LS, Goldstein I: Diabetic sexual dysfunction. Endocrinol Metab Clin North Am 1996; 25: 379–400 [DOI] [PubMed] [Google Scholar]
- 28. Hsieh JT, Lue TF, Muller SC: The influence of blood flow and blood pressure on penile erection. Int J Impot Res 1989; 1: 35–42 [Google Scholar]
- 29. Jaffe A, Chen Y, Kisch ES, Fischel B, Alon M, Stern N: Erectile dysfunction in hypertensive subjects. Assessment of potential determinants. Hypertension 1996; 28: 859–862 [DOI] [PubMed] [Google Scholar]
- 30. Keene LC, Davies PH: Drug‐related erectile dysfunction. Adverse Drug React Toxicol Rev 1999; 18: 5–24 [PubMed] [Google Scholar]
- 31. Barksdale JD, Gardner SF: The impact of first‐line antihypertensive drugs on erectile dysfunction. Pharmacotherapy 1999; 19: 573–581 [DOI] [PubMed] [Google Scholar]
- 32. Fogari R, Zoppi A, Poletti L, Marasi G, Mugellini A, Corradi L: Sexual activity in hypertensive men treated with valsartan or carvedilol: A crossover study. Am J Hypertens 2001; 14: 27–31 [DOI] [PubMed] [Google Scholar]
- 33. Muller SC, el‐Damanhoury H, Ruth J, Lue TF: Hypertension and impotence. Eur Urol 1991; 19: 29–34 [DOI] [PubMed] [Google Scholar]
- 34. el‐Rufaie OE, Bener A, Abuzeid MS, Ali TA: Sexual dysfunction among type II diabetic men: A controlled study. J Psychosom Res 1997; 43: 605–612 [DOI] [PubMed] [Google Scholar]